Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions

Xie, Xianju; Lin, Wang; Xing, Deke; Zhang, Ke; Weir, Michael D.; Liu, Huaibing; Bai, Yuxing; Xu, Hockin H.K.

doi:10.1016/j.dental.2017.03.002

Cited by 49 publications

(42 citation statements)

References 58 publications

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“…Not all the studies referred to a sample sterilization process before the antibacterial tests, and only 41 of the 82 studies specified the use of a specific protocol. Among these, a wide variety of techniques were employed, sterilization through ethylene oxide being the most commonly used [4,10,11,19,[26][27][28][29]33,34,36,37,40,[42][43][44][45][46][47][48][51][52][53][54]56,57,75,77]. Less commonly used sterilization techniques were: autoclave [3,58], gamma radiation [12,16,83], ultraviolet light [78,80,82,88,90], and incubation in 70% ethanol [30,91,92].…”

Section: Discussionmentioning

confidence: 99%

“…El-Wassefy et al, Saffarpour et al, and Xie et al immersed the samples in sterile water at 37 • C for 24 h [5,49,65], while others, such as Kasraei et al, stored the disks in distilled water at 24 • C for 24 h [3]. Some studies also used agitation techniques; Li et al, Melo et al, and Zhang et al placed the samples in water and agitated them for 1 h [4,42,44], while others, such as Xie et al, Wang et al, and Zhang et al, stored the disks in 200 mL of distilled water and agitated them with a magnetic stirrer at a speed of 100 rpm for 1 h [27,45,54]. Some studies combined both techniques: Chen et al agitated the disks in water for 1 h and then immersed them in distilled water at 37 • C for 1 day [51].…”

Section: Discussionmentioning

confidence: 99%

“…As in the previous subgroup, the teams of authors were interrelated, the only difference between the works being the type of monomer (dimethylaminohexane methacrylate (DMAHDM) or dimethylaminododecyl methacrylate (DMADDM)) incorporated into the resin. The last subgroup comprised studies that added the aforementioned nanoparticles to dental adhesives [34,[51][52][53][54][55][56][57]. Again, the author groups were interrelated, but as in the previous subgroup, the monomer added to the resin varied from study to study, and furthermore, some studies incorporated nanoparticles into all the adhesive components, while others only added them to the primer.…”

Section: Qualitative Analysismentioning

confidence: 99%

“…According to the inclusion criteria, each of the studies included a suitable control group that would make it possible to evaluate the effect of incorporating nanoparticles into the material on its antibacterial effect. In cases in which the nanoparticles were incorporated into a dental material synthesized from scratch, commercial material with a similar composition but without nanoparticles was used as a control group [8,[36][37][38][39][40][41][42][45][46][47][48][49][50]53,54,[75][76][77][78]. However, Argueta-Figueroa et al used 0.2% chlorhexidine and different antibiotics as control [79].…”

Section: Qualitative Analysismentioning

confidence: 99%

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Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

et al. 2020

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Background and Objectives: Nanotechnology has become a significant area of research focused mainly on increasing the antibacterial and mechanical properties of dental materials. The aim of the present systematic review and meta-analysis was to examine and quantitatively analyze the current evidence for the addition of different nanoparticles into dental restorative materials, to determine whether their incorporation increases the antibacterial/antimicrobial properties of the materials. Materials and Methods: A literature search was performed in the Pubmed, Scopus, and Embase databases, up to December 2018, following PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines for systematic reviews and meta-analyses. Results: A total of 624 papers were identified in the initial search. After screening the texts and applying inclusion criteria, only 11 of these were selected for quantitative analysis. The incorporation of nanoparticles led to a significant increase (p-value < 0.01) in the antibacterial capacity of all the dental materials synthesized in comparison with control materials. Conclusions: The incorporation of nanoparticles into dental restorative materials was a favorable option; the antibacterial activity of nanoparticle-modified dental materials was significantly higher compared with the original unmodified materials, TiO2 nanoparticles providing the greatest benefits. However, the high heterogeneity among the articles reviewed points to the need for further research and the application of standardized research protocols.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Qualitative Analysismentioning

confidence: 99%

Section: Qualitative Analysismentioning

confidence: 99%

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Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

et al. 2020

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“…+NACP adhesive continuously re-released Ca and P ions for 2-3 weeks 121 . Therefore, the rechargeable EBPM+NACP composite and PEHB+NACP adhesive provided the possibility for longterm remineralization.…”

Section: With Permission)mentioning

confidence: 99%

Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles

et al. 2019

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Tooth decay is prevalent, and secondary caries causes restoration failures, both of which are related to demineralization. There is an urgent need to develop new therapeutic materials with remineralization functions. This article represents the first review on the cutting edge research of poly(amido amine) (PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP). PAMAM was excellent nucleation template, and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization. NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities. PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates, superior acidneutralization, and ions release. Therefore, the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone. PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions. Besides, the long-term remineralization capability of PAMAM+NACP was established. After prolonged fluid challenge, the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration. Furthermore, the hardness of predemineralized dentin was increased back to that of healthy dentin, indicating a complete remineralization. Therefore, the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization, hardness increase, and caries-inhibition capabilities.

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Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Novel dental adhesive with triple benefits of calcium phosphate recharge, protein-repellent and antibacterial functions

Cited by 49 publications

References 58 publications

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

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