Novel Dermal Delivery Cargos of Clobetasol Propionate: An Update

Abstract

Dermal disorders such as psoriasis and eczema are associated with modifications in the chemical and molecular composition of the skin. Clobetasol propionate (CP), a superpotent topical glucocorticoid, is widely used for the therapeutic management of various skin conditions, owing to its strong anti-inflammatory, antipruritic, vasoconstrictive, and antiproliferative activities. Safety studies demonstrated that CP is safer for a shorter period, however, with prolonged application, it shows secondary side effects such as photosensitivity, Cushing-like syndrome, allergic contact dermatitis, osteonecrosis, hypopigmentation, steroid acne, and skin atrophy. Therefore, the US FDA (United States Food and Drug Administration) has restricted the usage of CP to not more than 15 days. Research scientists addressed its several formulations and drug delivery issues, such as low water solubility, less stability, photodegradation, and poor absorption, by incorporating them into novel nanobased delivery platforms. With the utilization of these technologies, these drawbacks of CP have been resolved to a large extent to reestablish this moiety. This article explores the physicochemical properties and mechanism of action of CP. Additionally, an attempt has been made to discover and highlight the possible features of the novel nanosystems, including nanoemulsions, nanosponges, solid lipid nanoparticles, nanostructured lipid carriers, and nanogels, reported for CP. The stability and safety concerns of CP, along with its commercial status, are also discussed.

Attenuated effects of topical vinpocetine in an imiquimod-induced mouse model of psoriasis

“…CLO, a prednisone predecessor, is the most frequently recommended steroidal antipsoriatic medication. 92 , 93 A recent study has indicated notable improvements in the unique characteristics of psoriasis-associated lesions with CLO treatment. These positive outcomes may potentially be attributed to the medication's anti-inflammatory, immunosuppressive, apoptotic, vasoconstricting, and anti-proliferative activities.…”

Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights

“…Microemulsions (MEs) are homogenous in appearance, single-phase, clear, and thermodynamically steady colloidal mixtures consisting of water, oil, co-surfactant, and surfactant, with droplets typically ranging up to 100 nm in size. Though a microemulsion has a smaller droplet size compared to Nes, both terms are still being used [ 54 ]. MEs present a promising platform for drug delivery, offering improved drug solubility, stability, absorption, and targeted delivery for enhanced therapeutic outcomes.…”

Biodegradable calcium carbonate carriers for the topical delivery of clobetasol propionate

“…CP is a high-potency synthetic GC widely used in dermatology to treat different dermatoses including psoriasis, 1 eczema, 2 lichen planus, 3 and seborrheic dermatitis. 4 Antiproliferative, immunosuppressive, vasoconstrictive, and anti-inflammatory actions of CP account for its broad therapeutic applicability; 5 however, at the same time, these features cause multiple local and even systemic adverse effects with long-term use. 6,7 Moreover, lipophilicity and poor aqueous solubility of CP result in its low permeation through the skin affecting its dermal bioavailability.…”

“…To date, a wide range of drug delivery systems have been proposed for topical CP administration, including the conventional forms, such as creams, ointments, and foams, 9 as well as more advanced ones, like polymer- and lipid-based vehicles. 5 Among the conventional CP formulations currently available on the market, Clobevate, Embeline, and Temovate are some of the most broadly used ones. However, it is also worth noting that the use of available topical forms can be inconvenient.…”