Environmental changes, global warming, and inappropriate planning are two sides of the worldwide water shortage coin [1-3]. Figure 1 shows the status of different countries based on water-stressed scenario [4]. Based on United Nations report, more than 2 billion people will experience water scarcity by 2050 [4]. All the previous projections show the vitality of drinking water production and desalination technologies. Currently, there exist two main commercial water-treatment process classes including thermal-based processes (including multistage flash distillation (MSF), vapor compression (VC), and multieffect distillation (MED)) and membrane filtration processes (including reverse osmosis (RO), nanofiltration (NF), and related energy recovery devices (ERD)). Thermal processes were more common previously. However, membrane technologies are outweighing the older processes. Main reasons for RO desalination process growth have mentioned to be rapid technical advances along with its simplicity and elegance [5-9]. Despite all advances in the field, fouling in its different types (colloidal matters, organic fouling of natural and synthetic chemicals, inorganic fouling (scaling), and biological fouling (biofouling)) is the remaining issue of industrial membrane processes [9, 10]. Various types of fouling will result in feed pressure increment and higher operational costs, more frequent requirement of chemical cleaning of the modules and shortened lifetime of the membranes. Fouling types happen simultaneously and could affect each other. This is while biofouling is identified as the critical issue as it is imposed to the membrane surface by living and dynamic microbiological cells and viruses. As the biological attachment, division of the cells and colonization on the surface occurs, the microbiological species and the exopolymeric substance produced by them, create resistance to antimicrobial treatments and the resulted biofouling starts to impose bio-corrosion and lowering the performance of the system [11]. Exposure of the membrane systems to feed's biological contamination highly depends on the environmental factors of the feed itself (nutrient content, available biological species, temperature, light, turbidity, and currents (tides and waves)) [12]. Items under feed water and microorganism classes are related to the microorganism proliferation and conditions supporting their existence. This is while main efforts over process enhancement and modification of membranes are attributed to the membrane-specific properties such as composition and surface structure-characteristics (classified under the title of membrane properties). Apparently, the issue of biofouling could own various levels of severity in different locations. Biofouling is mentioned to be responsible for 45% of the overall fouling that occurred in nanofiltration (NF) and RO plants [13-16].