This paper aims to investigate the crashworthiness capability of a commercial aircraft metallic sandwich leading edge, subjected to bird strike events. A sensitivity analysis is presented, aimed to assess the influence of the skin parameters (inner and outer faces and core thicknesses) on the leading-edge crashworthiness and to determine, among the configurations able to withstand a bird strike event, the best compromise in terms of weight and structural performances. In order to easily manage the design parameters and the output data, the ModeFrontier code was used in conjunction with the FE code Abaqus/Explicit. A dedicated python routine was developed to define a fully parametric simplified leading-edge model. To fulfill the aerodynamic requirements, the external surfaces were considered fixed during the sensitivity analysis, and, thus, only the internal leading edge’s components were modified to study their influence on the structural response. The total mass of the model, the maximum deformation and the energy dissipated due to material failure and the plastic deformations were monitored and used to compare and assess the behavior of each configuration.