Novel Development of Biocompatible Coatings for Bone Implants

Abstract

Prolonged life expectancy also results in an increased need for high-performance orthopedic implants. It has been shown that a compromised tissue-implant interface could lead to adverse immune-responses and even the dislodging of the implant. To overcome these obstacles, our research team has been seeking ways to decrease the risk of faulty tissue-implant interfaces by improving the biocompatibility and the osteo-inductivity of conventional orthopedic implants using ultrafine particle coatings. These particles were enriched with various bioactive additives prior to coating, and the coated biomaterial surfaces exhibited significantly increased biocompatibility and osteoinductivity. Physical assessments firstly confirmed the proper incorporation of the bioactive additives after examining their surface chemical composition. Then, in vitro assays demonstrated the biocompatibility and osteo-inductivity of the coated surfaces by studying the morphology of attached cells and their mineralization abilities. In addition, by quantifying the responses, activities and gene expressions, cellular evaluations confirmed the positive effects of these polymer based bioactive coatings. Consequently, the bioactive ultrafine polymer particles demonstrated their ability in improving the biocompatibility and osteo-inductivity of conventional orthopedic implants. As a result, our research team hope to apply this technology to the field of orthopedic implants by making them more effective medical devices through decreasing the risk of implant-induced immune responses and the loosening of the implant. OPEN ACCESSCoatings 2015, 5 738

Atomic layer deposition of nano-TiO_2 thin films with enhanced biocompatibility and antimicrobial activity for orthopedic implants

“…To develop biomaterials with combined biocompatible and antimicrobial surfaces, various surface modification or coating methods have been investigated. [39][40][41] In the present study, ALD, a well-established coating technique that is based on the sequential use of self-terminating surface reactions, was used to produce TiO 2 coatings at the nanoscale with different surface morphology and topography on the top of Ti substrates by controlling coating temperatures. Compared to other coating techniques, ALD is more adaptable for growing uniform films on large areas with precise film thickness control.…”

Biomineralization‐Inspired Green Synthesis of Zinc Phosphate‐Based Nanosheets in Gelatin Hydrogel

“…The TGA curves of composite samples generally occur in three regions: initial, main, and char decomposition regions. The first stage of weight loss for all samples was about 8% for the first 90°C due to the removal of the surface‐adsorbed water molecules . This weight loss was about 2% for gelatin‐free ZP clearly indicating lower content of water molecules in particles.…”

“…The first stage of weight loss for all samples was about 8% for the first 90°C due to the removal of the surface-adsorbed water molecules. [11][12][13][14]23,24 This weight loss was about 2% for gelatin-free ZP clearly indicating lower content of water molecules in particles. About 6% weight loss occurred for gelatin-free ZP sheets between 90 and 290°C, while we found 8% weight loss in the second region for ZP/ gelatin nanocomposite sheets.…”

Electrodeposited Biocoatings, Their Properties and Fabrication Technologies: A Review

“…The various coatings have been applied for many years in medicine to improve the properties of the interface between implants and tissues, which determine the biocompatibility and healing time. In past years, the reviews on such functional coatings for dental implantology [7], biocompatible coatings for bone implants [8], ion substituted hydroxyapatite thin films [9], titanium implants polymeric coatings [10], ceramic coatings for osteoporotic bones [11], and pulse laser deposited animal-originated calcium coatings [12] can be found.…”