Novel diamide derivatives: Synthesis, characterization, urease inhibition, antioxidant, antibacterial, and molecular docking studies

First In Vitro–In Silico Analysis for the Determination of Antimicrobial and Antioxidant Properties of 2-(4-Methoxyphenylamino)-2-oxoethyl Methacrylate and p-Acetamide

“…Additionally, these toxicological predictions are applied to Lipinski, Ghose, and Veber rules and bioavailability scores (Table ). Based on drug-likeness analysis, p -acetamide and MPAEMA were found to be consistent with the Lipinski, Veber, or Ghose rule. ,,− p -Acetamide and MPAEMA may be used as drugs for other molecules.…”

“…In this study, it can be said that the broad-spectrum antimicrobial effect of the p -acetamide molecule originates from the anisole functional groups. Similarly, in many studies, it has been reported that compounds having anisole and amide structures exhibit antibacterial properties against both Gram (+) and Gram (−) bacteria and Mycobacterium tuberculosis bacillus. − …”

“…For this reason, studies on the use of natural and synthetic antioxidants as antioxidants are becoming increasingly important today . Amide derivatives have an important place in the fields of medicine, pharmacy, and biology not only with their antimicrobial properties but also because of their antioxidant, anesthetic, and platelet aggregation activities. , …”

“…16 Amide derivatives have an important place in the fields of medicine, pharmacy, and biology not only with their antimicrobial properties but also because of their antioxidant, anesthetic, and platelet aggregation activities. 26,27 Malki et al investigated the antioxidant activity of five different amide derivatives (benzanilide, dodecanilide, Ncyclohexyloctamide, acetanilide, and acetaminophen (paracetamol)) using the DPPH, FRAP, and β-carotene linoleic acid method, and they determined that these amides showed significant antioxidant activity compared to reference antioxidants. In addition, they determined that the antioxidant effect increased with concentration.…”

Urease Inhibition and Structure‐Activity Relationship Study of Thiazolidinone‐, Triazole‐, and Benzothiazole‐Based Heterocyclic Derivatives: A Focus Review

“…The inhibitors of the urease can be categorized into two classes; substrate like inhibitors (hydroxyurea, hydroxamic acids) and mechanism based inhibitors (phosphorodiamidates). During the past years, extensive research has been done on the design and development of urease inhibitors such as hydroxamic acids, [51] urea and thiourea derivatives, [52] polyphenols, [53] isoniazids, [54] catechol-based inhibitors, [55] flavonoids, [56] coumarins, [57] indoles, [58] chalcones, [59] thiazoles, [60] thiazolidinones, [61] benzothiazoles, [62] benzoxazoles, [63] benzimidazoles, [64] barbituric acid and thiobarbituric acid derivatives, [65] quinazolinones, [66] triazoles, [67] phosphoramides, [68] sulfonamides, [69] thiadiazoles, [70] oxadiazoles, [71] thiosemicarbazones, [72] diamides, [73] benzenesulfonohydrazides [74] and many more. The most effec-tive inhibitors of urease cited in the literature are phosphorodiamide and phosphorotriamide derivatives such as NBPT (N-n butylthiophosphorictriamide), PPD (phenylphosphorodiamidate), NBPTO (N-n butylphosphorictriamide and flurofamide (Ndiaminophosphoryl-4-fluorobenzamide) [75] (Figure 6).…”