2022
DOI: 10.1016/j.molstruc.2022.132899
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Novel diastereoselective trans 2, 3-dihydrobenzofuran derivatives: Tandem synthesis, crystal structure, antioxidant and anticancer activity

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Cited by 10 publications
(2 citation statements)
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“…Some previous studies showed that these phenolic compounds mentioned exhibited antimicrobial, antiosteoporotic, and control of human tumors [32][33][34]. Our findings also found benzaldehyde, 2-hydroxy-4-methyl, and 2,3-dihydro-benzofuran in the R.A. Poir leaf extract, which exhibited strong antioxidant capacity and anticancer [35,36]. As can be concluded from the results, the identified compounds could be responsible for the ABTS radical scavenging activity of the extract obtained by the UAE method.…”
Section: Optimization and Comparison Of Uae Withsupporting
confidence: 77%
“…Some previous studies showed that these phenolic compounds mentioned exhibited antimicrobial, antiosteoporotic, and control of human tumors [32][33][34]. Our findings also found benzaldehyde, 2-hydroxy-4-methyl, and 2,3-dihydro-benzofuran in the R.A. Poir leaf extract, which exhibited strong antioxidant capacity and anticancer [35,36]. As can be concluded from the results, the identified compounds could be responsible for the ABTS radical scavenging activity of the extract obtained by the UAE method.…”
Section: Optimization and Comparison Of Uae Withsupporting
confidence: 77%
“…This may suggest that the cytotoxic activity observed in the extract is associated with the effect of this compound; selectivity against cancer cells was also observed. The selectivity index is commonly reported in the literature as a ratio of IC 50 values calculated for healthy cells and cancer cells [30,88], with values greater than 1 indicating desirable selectivity against cancer cells. The selectivity index of 2,3-dihydrobenzofuran (7) was 5.17, 1.53, 1.54, 1.65, and 1.15 for HeLa, PC-3, Huh-7, HepG2, and MCF-7 cells, respectively.…”
Section: Cytotoxic Effect Of the Compound 23-dihydrobenzofuranmentioning
confidence: 99%