Novel dinuclear gold(<scp>i</scp>) complexes containing bis(diphenylphosphano)alkanes and (biphenyl-2-yl)(di-<i>tert</i>-butyl)phosphane: synthesis, structural characterization and anticancer activity

Sulaiman, Adam A. A.; Ahmad, Saeed; Hashimi, Saeed Mujahid; Alqosaibi, Amany I.; Peedikakkal, Abdul Malik Puthan; Alhoshani, Ali; Alsaleh, Nasser B.; Isab, Anvarhusein A.

doi:10.1039/d2nj01680j

Cited by 3 publications

(3 citation statements)

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“…Thiosemicarbazones and their complexes have cytotoxic activity owing to their capacity to inhibit enzymes, like ribonucleotide reductase, topoisomerase II, and multidrugresistant protein (MDR1), by interfering with mitochondrial function and releasing reactive oxygen species (ROS) [21][22][23][24][25]. The investigation of gold complexes with various functional ligands that exhibit intriguing physical, chemical, biological, and pharmacological properties has garnered significant interest in recent years [26][27][28][29]. Specifically, gold(I) complexes that contain phosphane ligands have displayed anticancer properties, making them a compelling area of study [29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

“…Gold(I)-phosphane complexes have been shown to accumulate selectively in mitochondria, suggesting that this organelle may be their primary site of biological activity. The complexes' cytotoxic effects appear to be associated with their capacity to bind and The investigation of gold complexes with various functional ligands that exhibit intriguing physical, chemical, biological, and pharmacological properties has garnered significant interest in recent years [26][27][28][29]. Specifically, gold(I) complexes that contain phosphane ligands have displayed anticancer properties, making them a compelling area of study [29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

“…The investigation of gold complexes with various functional ligands that exhibit intriguing physical, chemical, biological, and pharmacological properties has garnered significant interest in recent years [ 26 , 27 , 28 , 29 ]. Specifically, gold(I) complexes that contain phosphane ligands have displayed anticancer properties, making them a compelling area of study [ 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Anticancer Activity of Phosphanegold(i) Complexes of 3-Thiosemicarbano-butan-2-one Oxime

Zarewa,

Binobaid,

Sulaiman

et al. 2023

Biomedicines

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Four novel phosphanegold(I) complexes of the type [Au(PR3)(DMT)].PF6 (1–4) were synthesized from 3-Thiosemicarbano-butan-2-one oxime ligand (TBO) and precursors [Au(PR3)Cl], (where R = methyl (1), ethyl (2), tert-butyl (3), and phenyl (4)). The resulting complexes were characterized by elemental analyses and melting point as well as various spectroscopic techniques, including FTIR and (1H, 13C, and 31P) NMR spectroscopy. The spectroscopic data confirmed the coordination of TBO ligands to phosphanegold(I) moiety. The solution chemistry of complexes 1–4 indicated their stability in both dimethyl sulfoxide (DMSO) and a mixture of EtOH:H2O (1:1). In vitro cytotoxicity of the complexes was evaluated relative to cisplatin using an MTT assay against three different cancer cell lines: HCT116 (human colon cancer), MDA-MB-231 (human breast cancer), and B16 (murine skin cancer). Complexes 2, 3, and 4 exhibited significant cytotoxic effects against all tested cancer cell lines and showed significantly higher activity than cisplatin. To elucidate the mechanism underlying the cytotoxic effects of the phosphanegold(I) TBO complexes, various assays were employed, including mitochondrial membrane potential, ROS production, and gene expression analyses. The data obtained suggest that complex 2 exerts potent anticancer activity against breast cancer cells (MDA-MB-231) through the induction of oxidative stress, mitochondrial dysfunction, and apoptosis. Gene expression analyses showed an increase in the activity of the proapoptotic gene caspase-3 and a reduction in the activity of the antiapoptotic gene BCL-xL, which supported the findings that apoptosis had occurred.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Anticancer Activity of Phosphanegold(i) Complexes of 3-Thiosemicarbano-butan-2-one Oxime

Zarewa,

Binobaid,

Sulaiman

et al. 2023

Biomedicines

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Dinuclear gold(I) complexes based on carbene and diphosphane ligands: bis[2-(dicyclohexylphosphano)ethyl]amine complex inhibits the proteasome activity, decreases stem cell markers and spheroid viability in lung cancer cells

Casagrande,

Borghese,

Corona

et al. 2023

J Biol Inorg Chem

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Gold complexes: a new frontier in the battle against lung cancer

Hanif,

Al-Rawi,

Ibrahim

et al. 2024

Reviews in Inorganic Chemistry

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Lung cancer is the second leading cause of the mortality related to the cancer. So, it is very necessary to explore the novel strategies to eradicate it. Currently, gold based medicinal compounds have emerged as remarkable anticancer agents and expressed strong potential against the lung cancer cell lines. This review provides a comprehensive overview of the history, advancements, and recent state of gold complexes in the treatment of the lung cancer. We discuss the biological evaluation in relation with the chemical structures of numerous gold complexes, including those featuring thiosemicarbazone, N-heterocyclic imine, N-heterocyclic carbenes, steroidyl NHC, CAACs, carbamates, and diphosphanes as ligands. Gold complexes’ cytotoxicity has been assessed and contrasted with that of standard drugs such as auranofin and cisplatin, with a special focus on IC50 values for evaluating potency. This review targets to deliver a detailed understanding of the potential of the gold complexes in lung cancer therapies, paving way for the future research and clinical applications.

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Novel dinuclear gold(i) complexes containing bis(diphenylphosphano)alkanes and (biphenyl-2-yl)(di-tert-butyl)phosphane: synthesis, structural characterization and anticancer activity

Cited by 3 publications

References 51 publications

Synthesis, Characterization, and Anticancer Activity of Phosphanegold(i) Complexes of 3-Thiosemicarbano-butan-2-one Oxime

Synthesis, Characterization, and Anticancer Activity of Phosphanegold(i) Complexes of 3-Thiosemicarbano-butan-2-one Oxime

Dinuclear gold(I) complexes based on carbene and diphosphane ligands: bis[2-(dicyclohexylphosphano)ethyl]amine complex inhibits the proteasome activity, decreases stem cell markers and spheroid viability in lung cancer cells

Gold complexes: a new frontier in the battle against lung cancer

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