Novel Dipeptidyl Peptidase IV Inhibitory and Antioxidant Peptides Derived from Human Gastrointestinal Endogenous Proteins

Dave, Lakshmi A.; Hayes, María; Moughan, Paul J.; Rutherfurd, Shane M.

doi:10.1007/s10989-016-9515-y

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…The total number of bioactive peptides predicted to be released ranged from 1 (secretin) to 39 (mucin-5AC), of which ACE-inhibitory peptides were the most frequently observed. These results were confirmed by an in vitro digestion assay of endogenous proteins, resulting in the release of a high number of antioxidant, ACE, and DPP-IV inhibitory peptides [ 185 , 186 ]. Similarly to dietary bioactive peptides that have been demonstrated to bind to specific receptors in the gut modulating gut motility, satiety, and the secretion of gastrointestinal endogenous proteins, peptides released from these endogenous proteins might also have effects on gut physiology and functions [ 187 ].…”

Section: Bioavailability Of Food Peptidesmentioning

confidence: 80%

Current Evidence on the Bioavailability of Food Bioactive Peptides

2020

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Food protein-derived bioactive peptides are recognized as valuable ingredients of functional foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases. However, although peptides have been demonstrated to exert multiple benefits by biochemical assays, cell culture, and animal models, the ability to translate the new findings into practical or commercial uses remains delayed. This fact is mainly due to the lack of correlation of in vitro findings with in vivo functions of peptides because of their low bioavailability. Once ingested, peptides need to resist the action of digestive enzymes during their transit through the gastrointestinal tract and cross the intestinal epithelial barrier to reach the target organs in an intact and active form to exert their health-promoting properties. Thus, for a better understanding of the in vivo physiological effects of food bioactive peptides, extensive research studies on their gastrointestinal stability and transport are needed. This review summarizes the most current evidence on those factors affecting the digestive and absorptive processes of food bioactive peptides, the recently designed models mimicking the gastrointestinal environment, as well as the novel strategies developed and currently applied to enhance the absorption and bioavailability of peptides.

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Section: Bioavailability Of Food Peptidesmentioning

confidence: 80%

Current Evidence on the Bioavailability of Food Bioactive Peptides

2020

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“…Two inhibitory peptides from endogenous proteins, predicted by in silico digestion, have confirmed in vitro their potentials: Met–Ile–Met from human serum albumin (IC 50 = 800.51 ± 4.90 µM) and Arg–Pro–Cys–Phe from endoribonuclease (IC 50 = 1,056.78 ± 61.11 µM). Although their IC 50 values do not indicate a strong inhibitory potential compared to Ile–Pro–Ile, endogenous proteins are a complementary source of bioactive peptides ( 99 ).…”

Section: Bioactive Peptides and Dpp-iv Activity: Glp-1 Activity Regulmentioning

confidence: 99%

Protein Digestion-Derived Peptides and the Peripheral Regulation of Food Intake

et al. 2017

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The gut plays a central role in energy homeostasis. Food intake regulation strongly relies on the gut–brain axis, and numerous studies have pointed out the significant role played by gut hormones released from enteroendocrine cells. It is well known that digestive products of dietary protein possess a high satiating effect compared to carbohydrates and fat. Nevertheless, the processes occurring in the gut during protein digestion involved in the short-term regulation of food intake are still not totally unraveled. This review provides a concise overview of the current data concerning the implication of food-derived peptides in the peripheral regulation of food intake with a focus on the gut hormones cholecystokinin and glucagon-like peptide 1 regulation and the relationship with some aspects of glucose homeostasis.

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Human Gastrointestinal Endogenous Proteins: A Recently Discovered Source of Gut Modulatory Peptides

Dave

2018

Novel Proteins for Food, Pharmaceuticals and Agriculture

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Novel Dipeptidyl Peptidase IV Inhibitory and Antioxidant Peptides Derived from Human Gastrointestinal Endogenous Proteins

Cited by 6 publications

References 52 publications

Current Evidence on the Bioavailability of Food Bioactive Peptides

Current Evidence on the Bioavailability of Food Bioactive Peptides

Protein Digestion-Derived Peptides and the Peripheral Regulation of Food Intake

Human Gastrointestinal Endogenous Proteins: A Recently Discovered Source of Gut Modulatory Peptides

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