Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-L-lactide)

Edlund, Ulrica; Albertsson, Ann‐Christine

doi:10.1002/(sici)1099-0518(19990615)37:12<1877::aid-pola17>3.0.co;2-4

Cited by 33 publications

(21 citation statements)

References 12 publications

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“…Microspheres can be formed by the evaporation of an organic solvent from dispersed oil droplets containing both the polymer and the drug [26][27][28][29][30][31][32]. Often, a double emulsion is employed; first the drug for encapsulation is dissolved in water; this aqueous phase is dispersed in an organic solvent, usually dichloromethane (or chloroform or ethyl acetate), which contains the degradable polymer and the primary water-in-oil (w/o) emulsion is formed.…”

Section: Solvent Evaporation Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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Mucoadhesive polymers have recently gained interest among pharmaceutical scientists as a means of improving drug delivery by promoting the residence time and contact time of the dosage form with the mucous membranes. Mucoadhesion is the process whereby synthetic and natural polymers adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug will be released at the site for an extended period of time. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery; however, coupling of mucoadhesive properties to microspheres has additional advantages like, a much more intimate contact with the mucus layer, efficient absorption and enhanced bioavailability of the drugs due to a high surface to volume ratio. The present review describes the potential applications of mucoadhesive microspheres as a novel carrier system to improve drug delivery by various routes of administration like buccal, oral, nasal, ocular, vaginal and rectal, either for systemic or for local effects. The mucoadhesive polymers, methods of preparation of microspheres and their in vitro and in vivo evaluation are also described.

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Section: Solvent Evaporation Methodsmentioning

confidence: 99%

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Patil

Sawant²

2008

CDD

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“…Using oil-in-water solvent evaporation [19], PHpr10-b-PCL (20 mg) was dissolved in 6 mL methylene chloride followed by adding AM with various weight ratios to polymer (1/0.1-1/1) served as model drug. The solution was added dropwise to 150 mL distilled water containing 1 wt% poly(vinyl alcohol) under vigorous stirring.…”

Section: Determination Of Drug Loading In Micellesmentioning

confidence: 99%

Synthesis of biodegradable poly(trans-4-hydroxy-N-benzyloxycarbonyl-l-proline)-block-poly(ε-caprolactone) copolymers and micellar characterizations

Lee

Yang

et al. 2005

Polymer

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“…Polyesters also constitute a family of degradable polymers of great and increasing interest since they can cover a wide range of applications as specialities, mainly in the biomedical field, and commodities [5][6][7][8][9][10][11]. Poly(alkylene dicarboxylate)s, a specific group within polyesters, are gaining increasing attention because the marketing of polybutylene succinate, which is supplied by Showa High Polymers as Bionolle TM and is characterized by a relatively low production cost, easy processability and good thermal and mechanical properties [12,14].…”

Section: Introductionmentioning

confidence: 99%

Study on the crystallization of poly(alkylene dicarboxylate)s derived from 1,9-nonanediol and mixtures with different ratios of azelaic acid and pimelic acid units

2015

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Polyalkylene dicarboxylates derived from 1,9-nonanediol and mixtures with different ratios of pimelic acid and azelaic acid were synthesized by thermal polycondensation.All samples had a high degree of crystallinity although it was found to decrease with the comonomer content.Crystallization kinetics of the two homopolymers and the copolymer with the eutectic composition was studied by calorimetric and optical microscopy techniques. Similar Avrami parameters were determined for the three samples and a spherulitic growth with heterogeneous nucleation was deduced. Spherulites showed negative birefringence and a fibrillar or ringed texture depending on the sample. Furthermore, clear differences were found in the primary nucleation density, the spherulitic growth rate and even in the secondary nucleation constant deduced from the Lauritzen-Hoffman treatment.The three studied samples had a similar arrangement of molecular chains, and consequently their WAXD patterns showed the same strong reflections related to the molecular packing. SAXS data revealed that a lamellar insertion mechanism was characteristic for non-isothermal crystallization from the melt. In addition, significant differences were found between the crystal lamellar thicknesses of the homopolymer and copolymer samples. Diffraction and spectroscopic data suggested that the lamellar crystals of the eutectic copolymer were mainly constituted by azelate units whereas the pimelate units were preferentially located in the amorphous regions including the interlamellar amorphous layer associated with the chain folds.

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Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-L-lactide)

Cited by 33 publications

References 12 publications

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Mucoadhesive Microspheres: A Promising Tool in Drug Delivery

Synthesis of biodegradable poly(trans-4-hydroxy-N-benzyloxycarbonyl-l-proline)-block-poly(ε-caprolactone) copolymers and micellar characterizations

Study on the crystallization of poly(alkylene dicarboxylate)s derived from 1,9-nonanediol and mixtures with different ratios of azelaic acid and pimelic acid units

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