Novel Drug Delivery Systems as an Emerging Platform for Stomach Cancer Therapy

Hani, Umme; Osmani, Riyaz Ali M.; Yasmin, Sabina; Gowda, B.H. Jaswanth; Ather, Hissana; Ansari, Yousuf; Siddiqua, Ayesha; Ghazwani, Mohammed; Fatease, Adel Al; Alamri, Ali H.; Rahamathulla, Mohamed; Begum, M. Yasmin; Wahab, Shadma

doi:10.3390/pharmaceutics14081576

Cited by 38 publications

(12 citation statements)

References 170 publications

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“…Stomach cancer incidence correlates with increasing age, and it has been chiefly diagnosed in men and in Asian and South American countries [20]. In recent years, different nature-based preventive and therapeutic strategies against stomach cancer disease in humans have been developed and evaluated [21]. Probiotics and postbiotic compounds have also widely been used as antitumor and cancer-preventive agents [22].…”

Section: Discussionmentioning

confidence: 99%

Effects of Probiotic Saccharomyces boulardii Supernatant on Viability, Nano-Mechanical Properties of Cytoplasmic Membrane and Pro-Inflammatory Gene Expression in Human Gastric Cancer AGS Cells

Pakbin

Allahyari

Dibazar

et al. 2023

IJMS

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Background: Gastric cancer has been recognized as the second most probable cause of death in humans from cancer diseases around the world. Postbiotics, supernatant, and metabolites from probiotic microorganisms have recently been used widely to prevent and treat cancer diseases in humans, without any undesirable side effects. This study explores the antiproliferative and antitumor activities of the probiotic Saccharomyces cerevisiae var. boulardii supernatant (SBS) against AGS cancer cells, a human gastric adenocarcinoma cell line. Methods: We evaluated cell growth inhibitory and mechanical properties of the cytoplasmic membrane and the downregulation of survivin and proinflammatory genes in AGS cells treated with SBS after 24 and 48 h. Results: SBS significantly inhibits the AGS cell growth, and the concentrations with IC50 values after 24 and 48 h treatments are measured as 2266 and 1956 µg/mL, respectively. Regarding the AFM images and Young`s modulus analysis, SBS significantly induces morphological changes in the cytoplasmic membrane of the treated AGS cells. Expression of survivin, NFƙB, and IL-8 genes is significantly suppressed in AGS cells treated with SBS. Conclusions: Considering the antitumor activities of SBS on AGS cell line, it can be regarded as a prospective therapeutic and preventive strategy against human stomach cancer disease.

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Section: Discussionmentioning

confidence: 99%

Effects of Probiotic Saccharomyces boulardii Supernatant on Viability, Nano-Mechanical Properties of Cytoplasmic Membrane and Pro-Inflammatory Gene Expression in Human Gastric Cancer AGS Cells

Pakbin

Allahyari

Dibazar

et al. 2023

IJMS

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“…In biomedical research, nanomaterials consisting of polymers, lipids, and inorganic materials have several potential applications [ 81 , 82 , 83 , 84 , 85 ]. The immunological homeostasis is interfered with by a wide range of NMs’ physicochemical features, which increase the unpredictability of nanomedicine in vivo [ 86 ].…”

Section: Physicochemical Properties Of Nanomaterials and Their Impact...mentioning

confidence: 99%

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

et al. 2023

Self Cite

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Immunotherapy shows a lot of promise for addressing the problems with traditional cancer treatments. Researchers and clinicians are working to create innovative immunological techniques for cancer detection and treatment that are more selective and have lower toxicity. An emerging field in cancer therapy, immunomodulation offers patients an alternate approach to treating cancer. These therapies use the host’s natural defensive systems to identify and remove malignant cells in a targeted manner. Cancer treatment is now undergoing somewhat of a revolution due to recent developments in nanotechnology. Diverse nanomaterials (NMs) have been employed to overcome the limits of conventional anti-cancer treatments such as cytotoxic, surgery, radiation, and chemotherapy. Aside from that, NMs could interact with live cells and influence immune responses. In contrast, unexpected adverse effects such as necrosis, hypersensitivity, and inflammation might result from the immune system (IS)’s interaction with NMs. Therefore, to ensure the efficacy of immunomodulatory nanomaterials, it is essential to have a comprehensive understanding of the intricate interplay that exists between the IS and NMs. This review intends to present an overview of the current achievements, challenges, and improvements in using immunomodulatory nanomaterials (iNMs) for cancer therapy, with an emphasis on elucidating the mechanisms involved in the interaction between NMs and the immune system of the host.

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“…Further screening is carried out if radiography results indicate the presence of tumour. Esophago-gastro duodenoscopy is a highly accurate, specific, reliable, and sensitive procedure, especially after coupling with endoscopic biopsy [29,30]. Endoscopic ultrasonography, computed tomography, laparoscopy are the other advanced techniques for detection of gastric carcinoma.…”

Section: Diagnosismentioning

confidence: 99%

Herbal bioactive encapsulated nano-formulations for the treatment of gastric cancer: a concise review

Rai,

Kaur,

Rawat

et al. 2023

Nano Futures

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Gastric cancer is a prominent cause of death globally. The major risk factors responsible for its development include age, H. pylori infection, excessive salt intake, and lack of fruits and vegetables in the diet. It is diagnosed using ultrasound, CT scan, endoscopic biopsy, and by detection of certain biomarkers. The conventional therapies for treatment of gastric cancer include the use of radiations, surgical resection, and chemotherapy. However, there are certain major issues associated with these treatments, like high risk of tumour reoccurrence, drug resistance development, less bioavailability of the drug at target site, rapid drug metabolism and high systemic toxicity due to drug doses.All such limitations of conventional treatments can be overcome with the use of herbal bio-actives as they exhibit less toxicity to normal healthy cells and reduce the risk of tumour recurrence and resistance development. Nano-formulations are developed to aid in targeted drug delivery, and to enhance the solubility, stability, bioavailability, and therapeutic efficacy of phytoconstituents. With the emergence of nanomaterials, different imaging modalities have been integrated into one single platform, and combined therapies with synergetic effects against gastric cancer were established. Moreover, the development of theragnostic strategies with simultaneous diagnostic and therapeutic ability was boosted by multifunctional nanoparticles. The present review discusses about the gastric cancer including its mortality rate, secular trends, pathophysiology, etiology, risk factors, diagnosis, and different treatment approaches with major emphasis on herbal bioactives (quercetin, paclitaxel, resveratrol, curcumin and ginsenosides) and different herbal constituent encapsulated nano-formulations (such as nanoparticles, niosomes, liposomes, nano-emulsion, and micelles). Challenges and future prospects of herbal bioactive encapsulated nano-formulations for the treatment/management of gastric cancers has been included in the later part of the manuscript.

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Novel Drug Delivery Systems as an Emerging Platform for Stomach Cancer Therapy

Cited by 38 publications

References 170 publications

Effects of Probiotic Saccharomyces boulardii Supernatant on Viability, Nano-Mechanical Properties of Cytoplasmic Membrane and Pro-Inflammatory Gene Expression in Human Gastric Cancer AGS Cells

Effects of Probiotic Saccharomyces boulardii Supernatant on Viability, Nano-Mechanical Properties of Cytoplasmic Membrane and Pro-Inflammatory Gene Expression in Human Gastric Cancer AGS Cells

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

Herbal bioactive encapsulated nano-formulations for the treatment of gastric cancer: a concise review

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