Novel drug delivery systems: Chitosan conjugates covalently attached to steroids with potential anticancer and agrochemical activity

Quiñones, Javier Pérez; Szopko, Richard; Schmidt, Claudia; Covas, Carlos Peniche

doi:10.1016/j.carbpol.2010.12.007

Cited by 28 publications

(13 citation statements)

References 30 publications

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“…Both, chitosan and its quaternized derivative, have been extensively studied for wound healing (Niekraszewicz 2005;Ong et al 2008), drug (Meng and Sturgis 2011;Park et al 2010;Pérez Quiñones et al 2011;Rajan and Raj 2013) and gene delivery (Dehousse et al 2010b;Mao et al 2010;Tang et al 2014), tissue engineering (Abdel-Fattah et al 2007;Croisier and Jérôme 2013;Kim et al 2008), in the form of gels (Anaya et al 2013;Das Neves and Bahia 2006), membranes (Silva et al 2013a, b), sponges (De Castro et al 2012;Noel et al 2010;Wang et al 2006), scaffolds (Huang et al 2005;Sajesh et al 2013;Vande Vord et al 2002;Zakhem et al 2012), micro-and nanoparticles (Agnihotri et al 2004;Dev et al 2010;Harris et al 2011;Songsurang et al 2011), fibres (Albanna et al 2013;Ma et al 2013;Zhou et al 2013) and nanofibres (Chen et al 2014;Fouda et al 2013;Tchemtchoua et al 2011;Toshkova et al 2010), as well as antimicrobial coatings for textiles (Wazed et al 2011;Zemljic et al 2009;Zemljič et al 2013). It has to be pointed out that present trend in chitosan use for fibre applications is in the nanoparticles preparation.…”

Section: Introductionmentioning

confidence: 99%

Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles

2015

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Adsorption of chitosan solution as well as chitosan nanoparticles dispersion onto cellulose fibres was implemented at pH = 4 and 7, respectively, in order to investigate the influence of different pH values on chitosan macromolecules' conformation and consequently on its adsorption ability and resultant coating morphology, as well as on antimicrobial activity of coated fibres. Adsorption capacity, charging behaviour and electrokinetical response of fibres at different pH values were analysed by determining zeta potential. Obtained results were related to the antimicrobial activity of fibres, determined by standard ASTM E2149 method.

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Section: Introductionmentioning

confidence: 99%

Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles

2015

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“…Therefore, chitosan will be a promising material for biomedical use [8,9] However, numerous studies report that the difficulties encountered when electrospinning pure chitosan [10,11]. Moreover, the weakness of mechanical properties will limit the practical performance of Chitosan in the medical application [12].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Curcumin Loaded Nano Polycaprolactone/Chitosan Nonwoven Fabric via Electrospinning Technique

Hoang¹

2018

JST

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Cucurmin loaded poly ε-caprolactone/chitosan (PCL/CTS) nanoscale nonwoven fabric was successfully fabricated using electrospinning, a facial and efficient method. The surface tensions of PCL/CTS blend solutions in various ratios were measured to evaluate the influence of PCL/CTS ratio on fibers formation. The effects of process parameter such as the applied voltage, tip-collector distance and the solution flow rate on the fiber generation and morphology of final fiber were optimized. Nanofibers morphology and structure were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), respectively. The prepared fibers had a smooth surface and fine morphology. The diameter of fibers ranges from 200 nm to 400 nm. The release kinetics of curcumin loaded samples were also analyzed via in vitro technique. Results demonstrated that the polycaprolactone/chitosan-based nanofibers encapsulate curcumin is a potential material for wound healing acceleration.

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“…To avoid degradation of chitosan and loss of its biological activity, crosslinking of biologically active molecules with chitosan should be carried out using mildly reactive reagents under mild conditions (e.g., near-neutral pH, room temperature, aqueous solution). Carbodiimide is an ideal reagent for satisfying the above reaction conditions and thus has been widely used in the synthesis of chitosan conjugates [32,38,46,[64][65][66][67][68][69][70][71][72][73]. Currently, there are three main types of condensing agents: dicyclohexylcarbodiimide (DCC) and diisopropylcarbodiimide (DIC), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC).…”

Section: Carbodiimide Chemistrymentioning

confidence: 99%

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

Qin

2020

IJMS

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As a natural polysaccharide, chitosan possesses good biocompatibility, biodegradability and biosafety. Its hydroxyl and amino groups make it an ideal carrier material in the construction of polymer-drug conjugates. In recent years, various synthetic strategies have been used to couple chitosan with active substances to obtain conjugates with diverse structures and unique functions. In particular, chitosan conjugates with antimicrobial activity have shown great application prospects in the fields of medicine, food, and agriculture in recent years. Hence, we will place substantial emphasis on the synthetic approaches for preparing chitosan conjugates and their antimicrobial applications, which are not well summarized. Meanwhile, the challenges, limitations, and prospects of antimicrobial chitosan conjugates are described and discussed.

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Novel drug delivery systems: Chitosan conjugates covalently attached to steroids with potential anticancer and agrochemical activity

Cited by 28 publications

References 30 publications

Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles

Electrokinetic properties of fibres functionalised by chitosan and chitosan nanoparticles

Fabrication of Curcumin Loaded Nano Polycaprolactone/Chitosan Nonwoven Fabric via Electrospinning Technique

Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications

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