Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects

Sharma, Vikas; Gupta, Madhu; Chauhan, Durgesh Nandini; Chauhan, Nagendra Singh; Goyal, Ramesh K.; Shah, Kamal

doi:10.1201/9781351057639-1

Cited by 2 publications

(3 citation statements)

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“…In addition to oxidative stress associated AGEs formation in diabetic patients, inflammatory reactions are another related condition connected to the development of various diabetes related complications [8]. Herein, the AgNPs showed a potent antiinflammatory activity with the AgNPs-JsL showing the highest trypsin inhibition and albumin denaturation inhibition percentage, followed by AgNPs-JsF, AgNPs-JsS and AgNPs-JsR.…”

Section: Discussionmentioning

confidence: 89%

“…Oxidative stress occupies the foremost role in the pathophysiology of diabetes which usually results from an imbalance between free radicals such as reactive oxygen species (ROS), and free radical scavengers (antioxidants). These ROS stimulate several pathways such as, glucosamine pathway, polyol pathway, electron transport system, protein kinase-C (PKC) which plays important roles in the growth and advancement of diabetes, and may also lead to lipid peroxidation, protein glycation, and pancreatic β-cell dysfunction, etc [8]. The possibility of treating diabetes using oral hypoglycemic agents with no side effects remain an unanswered question by medical practitioners, since various adverse effects have been associated with synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

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Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications

Awote,

Kazeem,

Ojekale

et al. 2023

PNgAS

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The wide range of secondary metabolites in medicinal plant extracts are used to treat and manage various diseases worldwide but more recently plant-mediated bio-nanotechnology is rapidly generating great research interest. Herein, the in-vitro study of the antidiabetic, anti-inflammatory, antiglycation, and antioxidant potentials of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts was evaluated. The synthesized AgNPs was characterized by UV-visible spectrophotometer, Fourier transform infrared spectroscopy (FT-IR) and Scanning electron microscopy (SEM). The antioxidant activity was evaluated via reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH), total antioxidant capacity (TAC) and nitric oxide scavenging assays; antidiabetic activity was evaluated with α-glucosidase and α-amylase inhibitory assays; antiglycation activity was evaluated using fructosamine inhibitory assay, and anti-inflammatory activity was performed using trypsin inhibitory and albumin denaturation assays. The AgNPs from all the plant parts showed good biological potentials investigated compared to the plant extracts however, the synthesized AgNPs using the leaf aqueous extract (AgNPs-JsL) showed a better antioxidant, antidiabetic, antiglycation, and anti-inflammatory potentials with an essential quality absorption band in the ultraviolet region of 410 nm and average size distribution of 50.47nm. In conclusion, all the parts of J. secunda showed substantial antidiabetic, antioxidant, antiglycation and anti-inflammatory potentials with high yield of various bioactive metabolites, however, the AgNPs-JsL was more potent followed by the flower, stem and roots extracts, respectively.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications

Awote,

Kazeem,

Ojekale

et al. 2023

PNgAS

View full text Add to dashboard Cite

show abstract

“…2 3.3.1. WISE color index classification Massaro et al (2012) introduced a method to identify blazars of uncertain type using a four-filters WISE color-color diagram (Sharma & Chauhan 2011). These authors identified a particular region in the diagram, which separates blazars from other source classes.…”

Section: Allwisementioning

confidence: 99%

Identifying the 3FHL Catalog. I. Archival Swift Observations and Source Classification

Kaur

Ajello

Marchesi

et al. 2019

ApJ

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We present the results of an identification campaign of unassociated sources from the F ermi Large Area Telescope 3FHL catalog. Out of 200 unidentified sources, we selected 110 sources for which archival Swif t-XRT observations were available, 52 of which were found to have exactly one X-ray counterpart within the 3FHL 95% positional uncertainty. In this work, we report the X-ray, optical, IR, and radio properties of these 52 sources using positional associations with objects in various catalogs. The W idef ield Inf rared Survey Explorer color-color plot for sources suggests that the most of these belong to the blazar class family. The redshift measurements for these objects range from z =0.277 to z =2.1. Additionally, under the assumption that the majority of these sources are blazars, three machine-learning algorithms are employed to classify the sample into flat spectrum radio quasars or BL Lacertae objects. These suggest that the majority of the previously unassociated sources are BL Lac objects, in agreement with the fact the BL Lac objects represent by far the most numerous population detected above 10 GeV in 3FHL.

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Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects

Cited by 2 publications

References 1 publication

Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications

Prospects of silver nanoparticles (AgNPs) synthesized by Justicia secunda aqueous extracts on diabetes and its related complications

Identifying the 3FHL Catalog. I. Archival Swift Observations and Source Classification

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