Novel drug delivery systems in topical treatment of psoriasis: Rigors and vigors

Abstract

Psoriasis is a chronic inflammatory skin disorder that may drastically impair the quality of life of a patient. Among the various modes of treatments for psoriasis, topical therapy is most commonly used in majority of patients. The topical formulations based on conventional excipients could serve the purpose only to a limited extent. With the advent of newer biocompatible and biodegradable materials like phospholipids, and cutting-edge drug delivery technologies like liposomes, solid lipid nanoparticles (SLNs), microemulsions, and nanoemulsions, the possibility to improve the efficacy and safety of the topical products has increased manifold. Improved understanding of the dermal delivery aspects and that of designing and developing diverse carrier systems have brought in further novelty in this approach. Substantial efforts and the consequent publications, patents and product development studies on the subject are the matter of interest and review of this article. However, majority of the work is related to the preclinical studies and demands further clinical assessment in psoriasis patients.

Formulation of tretinoin-loaded topical proniosomes for treatment of acne:in-vitrocharacterization, skin irritation test and comparative clinical study

“…One of the novel delivery systems is the use of vesicular systems, such as niosomes, whose effectiveness depends on their physicochemical properties. Vesicular systems have been widely studied as vehicles for dermal and transdermal drug delivery (Gupta et al, 2009;Katare et al, 2010). Their benefits in enhancing drug permeation have been well established (Gupta et al, 2009).…”

“…Newer developments in the formulation approach have raised hopes in making topical therapy more useful and acceptable (Katare et al, 2010). These new strategies, often called drug delivery systems (DDS) are based on delivery techniques that minimize toxicity, improve efficacy, offer great potential benefits to patients, and decrease side effects (Kaparissides et al, 2006).…”

Benzyl Benzoate-Loaded Microemulsion for Topical Applications: Enhanced Dermatokinetic Profile and Better Delivery Promises

“…Colloidal systems such as microemulsions have been investigated as drug delivery and targeting systems possessing a potential to modify bioavailability, stability, and side effects of various drugs (15)(16)(17)(18)(19)(20). Microemulsions (ME) are colloidal dispersions having droplet size in the range of 10 to 100 nm (18,21).…”

Pharmacological Benefits of Herbal Formulations in the Management of <i>Psoriasis vulgaris<i>

“…The topical formulations based on conventional excipients are replaced by new biocompatible and biodegradable vehicles (liposomes, microemulsions, solidlipid nanoparticles for bioactive molecules), in order to improve their efficacy and safety as well to allow a controlled delivery (Katare et al, 2010). Such vehicles are very compatible with lipophilic or hydrophilic plants extracts as well with pure compounds (psoralens, corticosteroids, levulinic acid, theophiline, vitamin D analogies).…”