Novel drug targeting and delivery techniques: Avenues for the advancement of neuropharmacology

Sitta, Ramsey

doi:10.4103/bc.bc_10_18

Cited by 1 publication

(1 citation statement)

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“…Pharmacological agents are also not without problems-poor target specificity and minimal permeability of the blood-brain barrier, coupled with systemic side effects during long-term use, nullify their efficacy (Sitta, 2018;Zaarour et al, 2021). Therefore, the successful development of autophagy-based treatment strategies for neurodegeneration will require improvements in central nervous system (CNS) delivery, optimization of treatment duration and timing, and enhancement of cell and tissue specificity (Ajoolabady et al, 2021).…”

Section: Therapeutic Potential Of Modulating Autophagymentioning

confidence: 99%

Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

Barmaki,

Nourazarian,

Khaki-Khatibi

2023

Front. Aging Neurosci.

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Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps, although it progressively weakens with aging and AD, thus facilitating the accumulation of toxic proteins and causing neurodegeneration. This review examines the impact of impaired autophagy on the progression of AD disease pathology. Under normal circumstances, autophagy removes abnormal proteins and damaged organelles, but any dysfunction in this process can lead to the exacerbation of amyloid and tau pathology, particularly in AD. There is increasing attention to therapeutic tactics to revitalize autophagy, including reduced caloric intake, autophagy-stimulating drugs, and genetic therapy. However, the translation of these strategies into clinical practice faces several hurdles. In summary, this review integrates the understanding of the intricate role of autophagy dysfunction in Alzheimer's disease progression and reinforces the promising prospects of autophagy as a beneficial target for treatments to modify the course of Alzheimer's disease.

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Section: Therapeutic Potential Of Modulating Autophagymentioning

confidence: 99%