Novel Drug Therapies and Diagnostics for Personalized Medicine and Nanomedicine in Genome Science, Nanoscience, and Molecular Engineering

Lin, Eugene

doi:10.4172/2167-7689.1000e116

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Precision medicine, an emerging branch of medicine, functions with prospects of the customization of healthcare (i.e. medical practices, decisions and treatments are tailored to individual patients [169]). The introduction of automatized embryo morphological evaluation using time-lapsed imaging in conjunction with using artificial intelligence (AI) is an attractive possibility [15].…”

Section: Emerging Trends and Future Challengesmentioning

confidence: 99%

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

et al. 2020

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Infertility affects approximately 15–20% of individuals of reproductive age worldwide. Over the last 40 years, assisted reproductive technology (ART) has helped millions of childless couples. However, ART is limited by a low success rate and risk of multiple gestations. Devising methods for selecting the best gamete or embryo that increases the ART success rate and prevention of multiple gestation has become one of the key goals in ART today. Special emphasis has been placed on the development of non-invasive approaches, which do not require perturbing the embryonic cells, as the current morphology-based embryo selection approach has shortcomings in predicting the implantation potential of embryos. An observed association between embryo metabolism and viability has prompted researchers to develop metabolomics-based biomarkers. Nuclear magnetic resonance (NMR) spectroscopy provides a non-invasive approach for the metabolic profiling of tissues, gametes and embryos, with the key advantage of having a minimal sample preparation procedure. Using NMR spectroscopy, biologically important molecules can be identified and quantified in intact cells, extracts or secretomes. This, in turn, helps to map out the active metabolic pathways in a system. The present review covers the contribution of NMR spectroscopy in assisted reproduction at various stages of the process.

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Section: Emerging Trends and Future Challengesmentioning

confidence: 99%

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

et al. 2020

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“…Precision medicine, an emerging field of medicine, is becoming the cornerstone of medical practices with prospects of the customization of healthcare, which means medical decisions, practices, and treatments are tailored to individual patients [3]. The use of genomic biomarkers, such as multi-omics data, has played a major role in precision medicine in oncology and other chronic diseases such as asthma [4], mental disorders [5, 6], and diabetes [7–9].…”

Section: Introductionmentioning

confidence: 99%

Machine learning and systems genomics approaches for multi-omics data

2017

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In light of recent advances in biomedical computing, big data science, and precision medicine, there is a mammoth demand for establishing algorithms in machine learning and systems genomics (MLSG), together with multi-omics data, to weigh probable phenotype-genotype relationships. Software frameworks in MLSG are extensively employed to analyze hundreds of thousands of multi-omics data by high-throughput technologies. In this study, we reviewed the MLSG software frameworks and future directions with respect to multi-omics data analysis and integration. Our review was targeted at researching recent approaches and technical solutions for the MLSG software frameworks using multi-omics platforms.

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“…A medicina de precisão, um campo emergente da medicina, é um importante conjunto de práticas médicas com perspectivas de customização dos cuidados de saúde, tornando as decisões, práticas e tratamentos médicos personalizados para cada paciente [8]. O uso de dados multiômicos, como biomarcadores genômicos, tem desempenhado um papel importante na medicina de precisão, por exemplo, na área da oncologia.…”

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Agrupamento Fuzzy Aplicado À Integração De Dados Multi-Ômicos

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Novel Drug Therapies and Diagnostics for Personalized Medicine and Nanomedicine in Genome Science, Nanoscience, and Molecular Engineering

Cited by 7 publications

References 11 publications

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

Machine learning and systems genomics approaches for multi-omics data

Agrupamento Fuzzy Aplicado À Integração De Dados Multi-Ômicos

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