Novel dry cryotherapy system for cooling the equine digit

Morgan, Joe P.; Stefanovski, Darko; Lenfest, Margret; Chatterjee, Souvik; Orsini, James A.

doi:10.1136/vetreco-2017-000244

Cited by 11 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its use has been more widespread in inflammatory forms of laminitis, where prediction of laminitis onset is easier than for endocrinopathic laminitis, where disease onset can be latent and insidious. Cooling of the limb can achieve a reduction in the severity of the lesion in acute disease (van Eps et al 2004), and research is continuing into the timelines, temperatures and types of cooling that can achieve the best outcomes (van Eps and Orsini 2016; Morgan et al 2018), while minimising pathologies associated with prolonged cooling (Proctor-Brown et al 2018).…”

Section: Vasoactive Aminesmentioning

confidence: 99%

A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis

Laat

Sillence

2020

Anim. Prod. Sci.

View full text Add to dashboard Cite

Despite the prevalence of endocrinopathic laminitis, the pharmacologic options for preventing and treating the disease are severely limited. The present review aims to discuss the spectrum of potential therapeutic agents for the condition, ranging from early experimental compounds to agents nearing registration. There are different pharmacologic targets for, and approaches to, managing laminitis. Reducing hyperinsulinaemia is central to diminishing endocrinopathic laminitis risk, and a detailed understanding of the pathophysiology of insulin dysregulation is necessary to identify pathways that can be targeted to minimise post-prandial insulin secretion and action. This area of research is advancing rapidly, with several exciting prospects, such as sodium-dependent glucose co-transporter-2 inhibitors, on the horizon for the treatment of equine metabolic dysfunction. Drugs that directly target the lamellae and aim to reduce the damage inflicted on the lamellae as part of this condition, are not yet available. Although progress in this area of laminitis therapy is slower, improved understanding of the events that lead to lamellar failure has enabled the investigation of novel drugs that aim to prevent laminitis at the site of the lesion. Finally, a brief review is included of the directions being taken in the management of the chronic and acute pain that accompanies laminitis. Medications for relieving the pain associated with laminitis are currently the most-prescribed drugs for the disease, and range from simple, affordable and thoroughly tested options, such as phenylbutazone, to newer, less-understood applications such as paracetamol and gabapentin. In the future, endocrinopathic laminitis management plans will likely take a multi-faceted approach that still hinge on effective dietary management and exercise, but also include drugs that address foot pathology, pain and underlying endocrine disturbances.

show abstract

Section: Vasoactive Aminesmentioning

confidence: 99%

A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis

Laat

Sillence

2020

Anim. Prod. Sci.

View full text Add to dashboard Cite

show abstract

“…The contrast therapy device was able to repeatably cool and heat tissues over the three hot:cold cycles lasting approximately 2 hours. This is a significant improvement over other forms of topical heat or cold therapies which often produce wide fluctuations in tissue temperatures depending on the type and application 11 . The ability to measure in real time the temperature of the fluid media being delivered to the tissues is critical from a therapeutic perspective and has important safety implications that are not possible with any other forms of cryotherapy or heating modalities 3,6 .…”

Section: Discussionmentioning

confidence: 99%

Contrast therapy: Tissue heating and cooling properties within the equine distal limb

Haussler

Wilde

Davis

et al. 2020

Equine Veterinary Journal

View full text Add to dashboard Cite

Background: Rehabilitation of tendon injuries in horses often involves cryotherapy to reduce inflammation and occasionally tissue heating to increase collagen extensibility. The application of alternating cold and hot (ie contrast therapy) is widely used in human physical therapy; however, its utility in equine rehabilitation is largely unknown. Objectives: The objectives of this study were to (a) assess if the equipment could achieve therapeutic tissue temperatures (<15 and >40°C) at different tissue depths relative to the digital flexor tendons and (b) evaluate the time-temperature profiles during serial heating and cooling cycles using a contrast therapy device. Study design: In vivo experiment. Methods: In 4 adult horses with normal forelimb digital flexor tendons, fine-wire temperature probes were placed superficially on the skin and implanted subcutaneously, deep to the superficial digital flexor tendon (SDFT) and deep to the deep digital flexor tendon (DDFT). Temperatures were recorded over three complete thermal (hot-cold) cycles. Minimum and maximum temperatures were recorded and the rate of temperature changes and the areas underneath the time-temperature curves (ie thermal load) were calculated. Results: Minimum and maximum tissue temperatures (°C) included: superficial skin [12.6 ± 1.0; 42.4 ± 2.4], subcutaneous tissues [14.1 ± 0.8; 42.3 ± 2.2], deep to the SDFT [15.6 ± 0.8; 41.7 ± 2.6] and deep to DDFT [25.1 ± 2.0; 38.0 ± 3.5]. An initial rapid rate of tissue temperature change between 3.2 and 4.3°C/min occurred within tissues to the depth of the DDFT. Tissue thermal loads during heating ranged from 255 to 607°C*second and from 309 to 780°C*second during tissue cooling, with the lower values noted deep to the DDFT. Main limitations: Unknown clinical efficacy in diseased tissues. Conclusions: The applied contrast therapy was consistently able to induce cooling and heating of tissues to the depth of the DDFT.

show abstract

“…3 To achieve beneficial effects, suggested target tissue temperatures should be maintained in the range of 10-19 C for 15-20 minutes. 4,5 A variety of cooling methods for the equine foot have been studied, [6][7][8][9] but few studies have evaluated cooling methods for other areas of the equine limb. 4,[10][11][12] A dry sleeve cryotherapy system designed for use in horses (Game Ready Equine, Concord, California) is a portable, easily applied commercial system that can be used in a variety of settings to apply cryotherapy to the distal limb of horses.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of a commercial dry sleeve cryotherapy system for cooling the equine metacarpus

2022

View full text Add to dashboard Cite

Objective To determine the ability of a commercial cryotherapy system (Game Ready Equine) to cool the metacarpal subcutaneous tissue and the superficial digital flexor tendon (SDFT) in horses. Study design Experimental study. Animals or sample population Six healthy adult horses. Methods Thermocouples were implanted into the metacarpal subcutaneous tissues and the SDFT of six horses. Two treatments (cryotherapy or cryotherapy with 5–50 mmHg intermittent compression) were randomly assigned to forelimbs and performed for 20 minutes. Temperatures were compared to the target range of 10–19°C and between groups. Results Only one limb in the cryotherapy/compression group reached the target range after cryotherapy. Temperatures did not differ between treatment groups at time 0. Lowest temperatures achieved in the subcutaneous tissue (p = .0043) and SDFT (p = .005) were 4.9 and 7.6°C lower when intermittent compression was applied. Similarly, applying compression induced a maximum change in temperature of approximately 7.0°C in the subcutaneous tissue (p = .014) and 10.2°C in the SDFT (p = .0001). Conclusion The cryotherapy system did not cool equine subcutaneous tissue or SDFT to the target temperature range, except in one limb. Combining cryotherapy with intermittent compression did result in lower temperatures and a greater change in temperature of the subcutaneous tissue and SDFT. Clinical significance When using this cryotherapy system, the addition of intermittent compression should be considered to achieve lower temperatures and potentially greater reduction in inflammation. Further studies are warranted to determine the effect of longer treatment times, higher compression settings, and the optimal temperature for benefits in normal and diseased equine tissues.

show abstract

Novel dry cryotherapy system for cooling the equine digit

Cited by 11 publications

References 23 publications

A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis

A review of recent developments in the pharmacological prevention and treatment of endocrinopathic laminitis

Contrast therapy: Tissue heating and cooling properties within the equine distal limb

Efficacy of a commercial dry sleeve cryotherapy system for cooling the equine metacarpus

Contact Info

Product

Resources

About