2024
DOI: 10.1002/ijc.35098
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Novel ectopic expression of zona pellucida 3 glycoprotein in lung cancer promotes tumor growth

Kamila Pulawska‐Moon,
Donata Ponikwicka‐Tyszko,
Weronika Lebiedzinska
et al.

Abstract: Zona pellucida 3 (ZP3) expression is classically found in the ZP‐layer of the oocytes, lately shown in ovarian and prostate cancer. A successful ZP3 ovarian cancer immunotherapy in transgenic mice suggested its use as an attractive therapeutic target. The biological role of ZP3 in cancer growth and progression is still unknown. We found that ~88% of the analyzed adenocarcinoma, squamous and small cell lung carcinomas to express ZP3. Knockout of ZP3 in a ZP3‐expressing lung adenocarcinoma cell line, significant… Show more

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