Novel effect of Arthrocen (avocado/soy unsaponifiables) on pentylenetetrazole-induced seizure threshold in mice: Role of GABAergic pathway

Goudarzi, Ramin; Zamanian, Golnaz; Partoazar, Alireza; Dehpour, Ahmad Reza

doi:10.1016/j.yebeh.2019.106500

Cited by 9 publications

(6 citation statements)

References 35 publications

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“…Pentylenetetrazol (PTZ) is a pro-convulsant used to model experimental epilepsy [45,46], where it induces epileptic seizures mainly via binding to the γ-aminobutyric acid (GABA A ) receptor and hindering the neuroinhibitory potential of GABA [47]. In a PTZ (50 mg/kg, I.P.)…”

Section: Alpha-synuclein-mediated Neurodegeneration: Implication In Epileptogenesismentioning

confidence: 99%

Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

Paudel

Angelopoulou

Piperi

et al. 2020

Biology

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Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently gained increased attention. Owing to the fact that neurodegenerative disease and epileptogenesis possibly share a common underlying mechanism, targeting neurodegenerative proteins against epileptogenesis might represent a promising therapeutic approach. Herein, we review the association of neurodegenerative proteins, such as α-synuclein, amyloid-beta (Aβ), and tau protein, with epilepsy. Providing insight into the α-synuclein, Aβ and tau protein-mediated neurodegeneration mechanisms, and their implication in epileptogenesis will pave the way towards the development of new agents and treatment strategies.

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Section: Alpha-synuclein-mediated Neurodegeneration: Implication In Epileptogenesismentioning

confidence: 99%

Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

Paudel

Angelopoulou

Piperi

et al. 2020

Biology

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“…It is determined that neuronal cell damage can lead to the loss of functional activities depending on the area of injury and the amount of cell damage following cerebral ischemia (Helps & Sims, 2007 ). Beneficial dietary supplementation with ASU has been observed in the reduction of the seizure (Goudarzi, Zamanian, et al, 2020 ), and neuroprotective effect on rat hippocampus subjected to global brain ischemia (Yaman et al, 2007 ) in animal models.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that ASU compound plays a key role in the treatment of osteoarthritis (OA), reducing pain and inflammation (Goudarzi, Nasab, et al, 2020 ; Taylor et al, 2017 ), as well as reducing the expression of inflammatory cytokines and prostaglandin E2 and inhibition of COX‐2 (Au et al, 2007 ). Recent studies have also shown that ASU has anticonvulsant (Goudarzi, Zamanian, et al, 2020 ) and anti‐ischemic effects (Yaman et al, 2007 ) in animal models.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of arthrocen on neuroinflammation and behavior like depression in stroke in a murine model

Goudarzi¹,

Zamanian

Seyyedian

et al. 2022

Food Science & Nutrition

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Stroke is a considerable reason for death, disability, socioeconomic loss, and depression in the world. Notably, many attempts to the reduction of the complications of poststroke injuries like depression have failed so far. In this study, we aimed to evaluate the anti‐inflammatory effect of arthrocen, avocado/soybean unsaponifiables (ASU), in the poststroke injuries like depression improvement in a mice model. We examined the antidepressant‐like effect of arthrocen using the forced swimming test and tail suspension test in mice subjected to stroke. Furthermore, immunohistochemistry of proinflammatory cytokines, IL‐10 and TNF‐α, and neural cell count were performed in the ischemic brain hippocampus of mice. Oral arthrocen reduced significantly (p < .001) the immobility time in the forced swimming test and tail suspension test in the stroke animals. Also, immunohistochemistry analysis of the hippocampus indicated significantly (p < .01) the reduction of IL‐10 and TNF‐α cytokines production. Nissl staining showed a significant (p < .0001) increase in the number of viable neurons in stroke mice receiving arthrocen. In conclusion, our data revealed the antidepressant activity of arthrocen in the stroke mice which may be the result of its anti‐inflammatory and neuroprotective role.

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“…15 minutes before diazepam (0.02 mg/kg) and 20 min before IVM (0.2 mg/kg). The mentioned dose and time intervals were based on our previous studies [ 51 , 53 , 54 ].…”

Section: Methodsmentioning

confidence: 99%

Anticonvulsant effects of ivermectin on pentylenetetrazole- and maximal electroshock-induced seizures in mice: the role of GABAergic system and KATP channels

Manavi¹,

Jafari²,

Shafaroodi³

et al. 2022

Heliyon

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Novel effect of Arthrocen (avocado/soy unsaponifiables) on pentylenetetrazole-induced seizure threshold in mice: Role of GABAergic pathway

Cited by 9 publications

References 35 publications

Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau

Beneficial effects of arthrocen on neuroinflammation and behavior like depression in stroke in a murine model

Anticonvulsant effects of ivermectin on pentylenetetrazole- and maximal electroshock-induced seizures in mice: the role of GABAergic system and KATP channels

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