Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling

Gao, Jiajia; Han, Lei; Liu, Ying; Liu, Honghong; Yang, Wan-cheng; Chang, Fen; Liu, Jing; Yu, Mei; Zhao, Jing

doi:10.1002/jcp.27802

Cited by 12 publications

(8 citation statements)

References 42 publications

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“…Autophagy is an essential contributor to multiple physiological and pathophysiological reactions, such as cellular viability and apoptosis (28,29). Emerging evidence has suggested that autophagy is essential for malignant progression (30)(31)(32)(33). In the present study, RV treatment upregulated the protein expression of Beclin 1 and LC3-II, and downregulated p62 expression levels in B16-F10 cells, demonstrating that RV may promote autophagy in melanoma.…”

Section: Discussionsupporting

confidence: 60%

Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K/AKT/mTOR signaling pathway

Gong¹,

Xia²

2019

Exp Ther Med

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Resveratrol (RV) is a natural polyphenolic phytoalexin derived from peanuts, red grape skins and red wine, and has been demonstrated to alleviate multiple types of malignancies. However, how RV achieves this in melanoma is unknown. The aim of present study was to investigate the role of RV in melanoma, using Cell Counting Kit-8, flow cytometry and western blot analysis. RV inhibited melanoma cell viability, migration and invasion counteracting melanoma progression. In addition, proteins associated with autophagy, including Beclin 1 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/I, were upregulated, whereas p62 expression was downregulated in RV-treated cells. The number of LC3 + puncta, which can be applied to represent autophagosome formation, increased following RV treatment, suggesting that RV may trigger autophagy in melanoma cells. Treatment with the autophagy inhibitor, 3-methyladenine, reversed the RV-dependent inhibition of viability, migration and invasion of melanoma cells. RV treatment also reduced the ratios of phosphorylated (p)-AKT/AKT and p-mTOR/mTOR in melanoma cells. In conclusion, these findings suggested that RV may inhibit the viability and migration of melanoma cells through inhibiting the AKT/mTOR pathway, thus triggering autophagy. This indicated that RV may serve as an innovative therapeutic for melanoma treatment.

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Section: Discussionsupporting

confidence: 60%

Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K/AKT/mTOR signaling pathway

Gong¹,

Xia²

2019

Exp Ther Med

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“…MAPK family includes proteins such as ERK, JNK and p38, which have been discovered to play essential roles in the migration of different cell types ( 21 , 22 ). In previous studies, there exists researches showing p38 signaling pathway in breast cancer cells is a key regulation pathway in the suppression of tumor metastasis ( 23 , 24 ). Zheng et al has demonstrated that inhibiting the phosphorylation of p-JNK and p-p38 can repress the migration of cervical cancer cells ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

B4GALNT1 enhances cell proliferation and growth in oral squamous cell carcinoma via p38 and JNK MAPK pathway

Jing¹,

Deng²,

Liang³

et al. 2020

Transl Cancer Res TCR

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Background Beta-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) was reported to play an important role in the development of the central nervous systems. We found higher expression of B4GALNT1 in oral squamous cell carcinoma (OSCC) tissues compared to the paired normal adjacent tissues in the TCGA database. This study aimed to investigate whether there was a potential relationship between B4GALNT1 and OSCC tumorigenesis and further explored the possible regulation mechanism. Methods Gene expression level was analyzed by means of real-time quantitative PCR and further cell function experiments were performed including cell proliferation and apoptosis test, cell cycle distribution detection after silencing B4GALNT1 by transfection with B4GALNT1-shRNA lentivirus. Western Blotting was carried out to explore the possible molecular mechanism. Results The present study confirmed the overexpression of B4GALNT1 in OSCC. Compared to the control group, cell proliferation after silencing B4GALNT1 was significantly inhibited and cell apoptosis percentage was significantly higher. Besides, the knockdown of B4GALNT1 resulted in cell cycle arrest at G1 phase in our experiment. Conclusions B4GALNT1 enhances the proliferation and suppress the apoptosis of OSCC cells probably through JNK and p38 signaling pathway.

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“…In a subsequent study they confirmed increased phosphorylation of Akt and ERK, but not JNK [10]. While NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway [21, 22]. Furthermore, their results indicated that some genes changed their expression without modifying the protein level, whereas for other genes, both the gene expression and corresponding protein expression was changed.…”

Section: Introductionmentioning

confidence: 95%

Emerging roles of low-density lipoprotein in the development and treatment of breast cancer

Guan¹,

Liu

Zhao

et al. 2019

Lipids Health Dis

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Breast cancer is a heterogeneous disease with increasing incidence and mortality and represents one of the most common cancer types worldwide. Low-density lipoprotein (LDL) is a complex particle composed of several proteins and lipids, which carries cholesterol into peripheral tissues and also affects the metabolism of fatty acids. Recent reports have indicated an emerging role of LDL in breast cancer, affecting cell proliferation and migration, thereby facilitating disease progression. However, controversy still exists among distinct types of breast cancer that can be affected by LDL. Classical therapeutic approaches, such as radiotherapy, chemotherapy, and lipid-lowering drugs were also reported as affecting LDL metabolism and content in breast cancer patients. Therefore, in this review we summarized and discussed the role of LDL in the development and treatment of breast cancer.

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Novel effects of sphingosylphosphorylcholine on the apoptosis of breast cancer via autophagy/AKT/p38 and JNK signaling

Cited by 12 publications

References 42 publications

Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K/AKT/mTOR signaling pathway

Resveratrol suppresses melanoma growth by promoting autophagy through inhibiting the PI3K/AKT/mTOR signaling pathway

B4GALNT1 enhances cell proliferation and growth in oral squamous cell carcinoma via p38 and JNK MAPK pathway

Emerging roles of low-density lipoprotein in the development and treatment of breast cancer

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