Novel electrochemical biosensing platform for microRNA: Bivalent recognition-induced nanoparticle amplification occurred in nanochannels

Jiang, Zilian; Jiao, Jiao; Li, Jianjun; Zhang, Hongfang; Zheng, Jianbin

doi:10.1016/j.snb.2021.130209

Cited by 12 publications

(7 citation statements)

References 42 publications

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“…The sensitivity of the voltammetric systems has been demonstrated to be improved with the use of nanoparticles with diameters small enough to enter inside the NAA pores for a more efficient blocking. An interesting application of voltammetry with nanoparticles is reported by Jiang et al [ 108 ] for the detection of microRNAs (miRNAs), important for early cancer diagnosis. [ 109 ] A bivalent recognition using SiO 2 nanoparticles produces the blocking of the NAA pores and therefore the amplification of the signal.…”

Section: Classification Of the Health Monitoring Naa Biosensors Based...mentioning

confidence: 99%

“…As explained before, traditional voltammetric systems are demonstrated to optimize their performance with nanochannels diameters mostly around 20 nm [ 100,104–107 ] and reaching exceptionally 50 nm. [ 99,102 ] On the contrary, when using nanoparticles for sensitivity improvement, the diameter of the NAA pores generally used is around 200 nm [ 108,110,111 ] as the nanoparticles are needed to enter inside the nanochannels and partially block them for signal amplification.…”

Section: Classification Of the Health Monitoring Naa Biosensors Based...mentioning

confidence: 99%

“…The former is detected and quantified with a molecular gate‐based system [ 153 ] and the latter with voltammetry. [ 108 ] Molecular gate‐based sensing platforms are also used for the detection of another oncomarker, 8‐oxo‐7,8‐dihydro‐2'‐deoxyguanosine (8‐oxo‐dG). [ 152 ] This molecule is a product of oxidative stress processes over nucleophilic bases in DNA.…”

Section: Naa Biosensors Detection Targetsmentioning

confidence: 99%

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Oligonucleotic Probes and Immunosensors Based on Nanoporous Anodic Alumina for Screening of Diseases

Xifré-Pérez

Ferré‐Borrull

Marsal

2022

Adv Materials Technologies

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This paper is an overview of the recent advances in nanoporous anodic alumina sensing platforms based on the interaction of oligonucleotides and antibodies with bioelements (e.g., virus, bacteria, or biomarkers) that can cause or identify diseases. Nanoporous alumina is the common platform material for all these sensing devices that have an enormous potential for the next‐generation bioanalytical systems. Nanoporous alumina is a cost‐effective material with morphological flexibility that provides high sensitivity to the sensing systems due to its large surface‐to‐volume ratio. Immunosensors transduce the signal produced by the specific antibody–antigen interaction. They are widely used for clinical analysis due to the high selectivity and sensitivity of their immunoreaction, transduced by different methods (electrochemical, optical, piezoelectric, etc). Another important, outstanding and more recently type of biosensors are based on the oligonucleotic functionalization of nanoporous alumina. Oligonucleotides can bind to a wide variety of elements (small organic molecules, proteins, or cells) with high selectivity, specificity, and affinity, even higher to those of antibodies. The basic concepts and mechanisms of their sensing methods for health care biosensing are introduced. Their transduction methods and great potential applications will be evaluated and classified in detail, together with a discussion of possible future trends.

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Section: Classification Of the Health Monitoring Naa Biosensors Based...mentioning

confidence: 99%

Section: Classification Of the Health Monitoring Naa Biosensors Based...mentioning

confidence: 99%

Section: Naa Biosensors Detection Targetsmentioning

confidence: 99%

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Oligonucleotic Probes and Immunosensors Based on Nanoporous Anodic Alumina for Screening of Diseases

Xifré-Pérez

Ferré‐Borrull

Marsal

2022

Adv Materials Technologies

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“…Besides nanoparticles, nanopores 11 and nanochannels 12,13 have also been used in several electrochemical sensors for miRNA detection. The nanopore- and nanochannel-based biosensing platforms offer a high-throughput, ultrasensitive single-molecule sensing device capable of label-free detection and quantification of ultralow concentrations of the target.…”

Section: Introductionmentioning

confidence: 99%

“…These extra forces, however, may alter the nanopore structure, preventing the molecules from normal movement through the pores. 16–18…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials in electrochemical nanobiosensors of miRNAs

Mousazadeh,

Daneshpour,

Rafizadeh Tafti

et al. 2024

Nanoscale

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Glucometer-based electrochemical biosensor for determination of microRNA (let-7a) using magnetic-assisted extraction and supersandwich signal amplification

Wang

Shan

et al. 2022

Microchim Acta

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Novel electrochemical biosensing platform for microRNA: Bivalent recognition-induced nanoparticle amplification occurred in nanochannels

Cited by 12 publications

References 42 publications

Oligonucleotic Probes and Immunosensors Based on Nanoporous Anodic Alumina for Screening of Diseases

Oligonucleotic Probes and Immunosensors Based on Nanoporous Anodic Alumina for Screening of Diseases

Nanomaterials in electrochemical nanobiosensors of miRNAs

Glucometer-based electrochemical biosensor for determination of microRNA (let-7a) using magnetic-assisted extraction and supersandwich signal amplification

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