Novel electrophoretic deposited nanostructured forsterite coating on 316L stainless steel implants for biocompatibility improvement

Hosseini, Seyedeh Narjes; Jazi, Hamidreza Salimi; Fathi, Mohammadhossein

doi:10.1016/j.matlet.2014.12.079

Cited by 14 publications

(1 citation statement)

References 11 publications

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“…Recently, the incorporation of forsterite with poly(lactic acid) using 3D printing and electrospinning technique produced promising material that could be attributed as a choice in bone tissue engineering [12]. In another study, nanostructured forsterite coated on stainless steel implants promoted their biocompatibility characteristic [13]. Moreover, forsterite was found retaining excellent fracture toughness when compared with hydroxyapatite or bio-glass [14, 15].…”

Section: Introductionmentioning

confidence: 99%

The physicochemical and biomechanical profile of forsterite and its osteogenic potential of mesenchymal stromal cells

et al. 2019

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It has been demonstrated that nanocrystalline forsterite powder synthesised using urea as a fuel in sol-gel combustion method had produced a pure forsterite (FU) and possessed superior bioactive characteristics such as bone apatite formation and antibacterial properties. In the present study, 3D-scaffold was fabricated using nanocrystalline forsterite powder in polymer sponge method. The FU scaffold was used in investigating the physicochemical, biomechanics, cell attachment, in vitro biocompatibility and osteogenic differentiation properties. For physicochemical characterisation, Fourier-transform infrared spectroscopy (FTIR), Energy dispersive X-ray (EDX), X-ray diffraction (XRD), Raman spectroscopy, X-ray photoemission spectrometer (XPS) and Brunauer-Emmett-Teller (BET) were used. FTIR, EDX, XRD peaks and Raman spectroscopy demonstrated correlating to FU. The XPS confirmed the surface chemistry associating to FU. The BET revealed FU scaffold surface area of 12.67 m 2 /g and total pore size of 0.03 cm 3 /g. Compressive strength of the FU scaffold was found to be 27.18 ± 13.4 MPa. The human bone marrow derived mesenchymal stromal cells (hBMSCs) characterisation prior to perform seeding on FU scaffold verified the stromal cell phenotypic and lineage commitments. SEM, confocal images and presto blue viability assay suggested good cell attachment and proliferation of hBMSCs on FU scaffold and comparable to a commercial bone substitutes (cBS). Osteogenic proteins and gene expression from day 7 onward indicated FU scaffold had a significant osteogenic potential ( p <0.05), when compared with day 1 as well as between FU and cBS. These findings suggest that FU scaffold has a greater potential for use in orthopaedic and/or orthodontic applications.

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