Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

Battle, Andrew R.; Valenzuela, Stella M.; Mechler, Ádám; Nichols, Ryan; Praporski, Slavica; Maio, Isabelle L. di; Islam, Hedayetul; Girard-Egrot, Agnès; Cornell, Bruce; Prashar, Jog; Caruso, Frank; Martin, L.; Martin, Donald K.

doi:10.1002/adfm.200800483

Cited by 28 publications

(20 citation statements)

References 36 publications

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“…A very elegant application of these new composite PEM films/ lipid membranes has been presented by Battle et al [231] An innovative engineered ion channel, gramicidin (bisgA), incorporated into the lipid membrane coating on a PSS/PAH microcapsule, was found to provide a functional capacity for controlling transport across the microcapsule wall. The microcapsules provided transport and permeation for drug-analog neutral species, as well as positively and negatively charged ionic species.…”

Section: Mimicking the Properties Of Natural Materialsmentioning

confidence: 97%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

695

702

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The design of advanced functional materials with nanometer- and micrometer-scale control over their properties is of considerable interest for both fundamental and applied studies because of the many potential applications for these materials in the fields of biomedical materials, tissue engineering, and regenerative medicine. The layer-by-layer deposition technique introduced in the early 1990s by Decher, Moehwald, and Lvov is a versatile technique, which has attracted an increasing number of researchers in recent years due to its wide range of advantages for biomedical applications: ease of preparation under "mild" conditions compatible with physiological media, capability of incorporating bioactive molecules, extra-cellular matrix components and biopolymers in the films, tunable mechanical properties, and spatio-temporal control over film organization. The last few years have seen a significant increase in reports exploring the possibilities offered by diffusing molecules into films to control their internal structures or design "reservoirs," as well as control their mechanical properties. Such properties, associated with the chemical properties of films, are particularly important for designing biomedical devices that contain bioactive molecules. In this review, we highlight recent work on designing and controlling film properties at the nanometer and micrometer scales with a view to developing new biomaterial coatings, tissue engineered constructs that could mimic in vivo cellular microenvironments, and stem cell "niches."

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Section: Mimicking the Properties Of Natural Materialsmentioning

confidence: 97%

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Boudou¹,

Crouzier²,

Ren³

et al. 2010

Advanced Materials

695

702

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“…Multicomponent films design with lipid bilayers and polyelectrolyte multilayers were described for the first time in 1993 153 Polyelectrolyte multilayers were inserted between transferred Langmuir‐Blodgett films to form a stack of different layers. Lipid bilayer membranes were also formed on polyelectrolyte films via adsorption followed by their fusion of unilamellar vesicles 154–156 Lipid bilayers deposited on exponentially growing multilayers can form a barrier onto which the build‐up of multilayers can be continued to lead to a new exponential growth regime independent from the growth regime obtained before the deposition of the lipid bilayer 157 Capsules based on combinations of polyelectrolyte multilayers and lipid bilayers have also been considered to take profit of the mechanical stability of polyelectrolyte assemblies and the very selective permeation features of lipid membranes 158, 159…”

Section: Physicochemical Aspects Allowing To Control the Lbl Deposmentioning

confidence: 99%

Dynamic Aspects of Films Prepared by a Sequential Deposition of Species: Perspectives for Smart and Responsive Materials

et al. 2011

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The deposition of surface coatings using a step-by-step approach from mutually interacting species allows the fabrication of so called "multilayered films". These coatings are very versatile and easy to produce in environmentally friendly conditions, mostly from aqueous solution. They find more and more applications in many hot topic areas, such as in biomaterials and nanoelectronics but also in stimuli-responsive films. We aim to review the most recent developments in such stimuli-responsive coatings based on layer-by-layer (LBL) depositions in relationship to the properties of these coatings. The most investigated stimuli are based on changes in ionic strength, temperature, exposure to light, and mechanical forces. The possibility to induce a transition from linear to exponential growth in thickness and to change the charge compensation from "intrinsic" to "extrinsic" by controlling parameters such as temperature, pH, and ionic strength are the ways to confer their responsiveness to the films. Chemical post-modifications also allow to significantly modify the film properties.

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“…7 The resulting polyelectrolyte multilayers (PEMs) can be manufactured in a controllable manner with respect to their physical and functional characteristics ( e.g. , thickness, permeability, and interfacial properties), making them useful in biomedical applications such as bionanoreactors, 8 nanofiltration, 4, 5 drug delivery, 9–11 and biosensors. 12–15 …”

Section: Introductionmentioning

confidence: 99%

A design full of holes: functional nanofilm-coated microdomains in alginate hydrogels

2013

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This study demonstrates the successful manufacture and functional characterization of alginate hydrogels containing a variety of encapsulates within polyelectrolyte multilayer-coated micropores. These microporous alginate (MPA) hydrogels are prepared via one-step internal ionotropic gelation of the alginate using polyelectrolyte multilayer-coated CaCO3 microspheres along with the weak acid glucono-δ-lactone. Here, successful encapsulation of a model macromolecule and fluorescent nanoparticles within microcapsules—distributed throughout the larger alginate hydrogel—is confirmed with confocal microscopy, while the porous morphology of the MPA hydrogels is examined with scanning electron microscopy. Hydrogels constructed with uncoated CaCO3 microspheres release their contents into the surrounding environment, while those constructed with polyelectrolyte multilayer-coated CaCO3 microspheres retain the materials within the pores. MPA hydrogels containing the model enzyme glucose oxidase retained activity and are capable of reacting with small molecules from the external environment. The ability to encapsulate an assortment of functional materials within a moldable, biocompatible alginate matrix gives this approach great flexibility and potential in a wide variety of biomedical applications.

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Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane

Cited by 28 publications

References 36 publications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Multiple Functionalities of Polyelectrolyte Multilayer Films: New Biomedical Applications

Dynamic Aspects of Films Prepared by a Sequential Deposition of Species: Perspectives for Smart and Responsive Materials

A design full of holes: functional nanofilm-coated microdomains in alginate hydrogels

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