Novel epidemiological features of moyamoya disease

Baba, Takeo; Houkin, Kiyohiro; Kuroda, Satoshi

doi:10.1136/jnnp.2007.130666

Cited by 388 publications

(296 citation statements)

References 13 publications

Supporting

Mentioning

267

Contrasting

Unclassified

Order By: Relevance

“…In addition, ethnic and regional differences in the incidence of moyamoya disease have been noted. In Japan, moyamoya disease is the most common pediatric cerebrovascular disease, with a prevalence of about three cases per 100,000 children 12, 13, 14. In the United States, incidence ratios are 4.6 for Asians, 2.2 for African‐Americans, and 0.5 for Hispanics, compared with Caucasians 15.…”

Section: Introductionmentioning

confidence: 99%

Incidence and long‐term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Chang

Liang

et al. 2016

Cancer Medicine

View full text Add to dashboard Cite

We aimed to investigate the incidence and long‐term outcome of moyamoya syndrome in pediatric patients with primary brain tumors after receiving cranial radiotherapy (RT) in a single institute in Taiwan. The complete medical records, medical images, and RT notes of 391 pediatric patients with primary brain tumors treated with cranial RT between January 1975 and December 2005 in Taipei Veterans General Hospital (TVGH), Taiwan, were entered into an electronic registry and reviewed. Eight (2%) cases of post‐RT moyamoya syndrome were identified in the sample of 391 patients. The median latency was 3 years post‐RT. Among the eight patients, three had craniopharyngioma, two had optic glioma, two had medulloblastoma, and one had a suprasellar astrocytoma. The prescribed physical doses of RT were in the range of 40–54 Gy. The incidence was highest in those with optic glioma (0.039/person‐year), followed by craniopharyngioma (0.013/person‐year), astrocytoma (0.003/person‐year), and medulloblastoma (0.002/person‐year). No patients died of vasculopathy. No difference in crude incidence was found between our results and those of other series. The incidence of moyamoya syndrome was diagnosis dependent, with the highest incidence among patients with optic glioma. No regional difference in incidence was found. Long‐term, stable neurological function may be achieved following timely surgical intervention.

show abstract

Section: Introductionmentioning

confidence: 99%

Incidence and long‐term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Chang

Liang

et al. 2016

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…An all-inclusive survey in Hokkaido performed from 2002 to 2006 estimated the annual prevalence of moyamoya disease as 10.5 per 100,000 individuals, and the annual incidence as 0.94 per 100,000 individuals. 1) The discrepancy between these two studies may been caused by differences in the survey methods or survey areas.…”

Section: Epidemiological Features Of Moyamoya Disease In Japanmentioning

confidence: 99%

Epidemiological Features of Moyamoya Disease in Japan

Hoshino

Izawa

Suzuki

2012

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

To clarify the clinical features of moyamoya disease in Japan, 941 patients with definite moyamoya disease were analyzed from the databases constructed by the Research Committee on Moyamoya Disease, established by the Ministry of Health, Labour and Welfare. Moyamoya disease occurs much more frequently among women than men, with a female-to-male ratio of 1.98. A family history of the disease was observed in 14.9%. The age at onset was characterized by two peaks: one at 5-9 years and another lower peak at around 40 years. Initial clinical features were transient ischemic attack in 46%, infarction in 20%, hemorrhage in 21%, headache in 6%, and epilepsy in 4%. The distribution of the age at onset showed one peak at around 40 years in patients with hemorrhage but two peaks in patients with ischemia.

show abstract

“…37) Moyamoya syndrome has also been reported in patients with other diseases of known genetic origin, such as neurofibromatosis type I and Down syndrome, among others, highlighting the evidence for a possible genetic etiology for this severe disease. 37) Additionally, the following facts suggest a multifactorial etiology of moyamoya disease: the predisposition of familial occurrence, 6,71,76) the non-Mendelian pattern of inheritance in familial cases. 44,50) Based on these considerations, some researchers believe that moyamoya disease is inherited in a polygenic or autosomal dominant mode with a low penetrance.…”

Section: Geneticsmentioning

confidence: 99%

“…So far, many new aspects of the epidemiology have been uncovered and innovations in surgical treatment have been developed, including direct bypass surgery and other combined revascularization treatments. 6,36,37,71) Despite these many and extensive studies, however, the mechanism of moyamoya disease is still unknown. From a historical point of view, some of the hypotheses are now considered to be historical achievements.…”

Section: Introductionmentioning

confidence: 99%

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Houkin

Ito

Sugiyama

et al. 2012

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

Research on moyamoya disease has progressed remarkably in the past several decades. Indeed, many new facts concerning the epidemiology of the disease have been revealed and surgical treatments have been drastically improved. However, despite extensive research, the mechanism of moyamoya disease is still unknown. Consequently, the cardinal treatment of this disease has not yet been developed. For further clarification of its etiology, innovative studies are therefore indispensable. The aim of this paper is to review research on the pathogenesis of moyamoya disease to identify milestones in the direction of its true solution. Many hypotheses of the pathogenesis of moyamoya disease have been proposed in the past half century, including infection (viral and bacterial), autoimmune disorders, proteins abnormality, and gene abnormality. Some of these are now considered to be historical achievements. Others, however, can be still subjected to contemporary research. Currently, several genetic abnormalities are considered to offer the most probable hypothesis. In addition, interesting papers have been presented on the role of the endothelial progenitor cell on the pathogenesis of moyamoya disease. Intuitively, however, it appears that a single theory cannot always explain the pathogenesis of this disease adequately. In other words, the complex mechanism of several factors may comprehensively explain the formation of moyamoya disease. The``double hit hypothesis'' is probably the best explanation for the complicated pathology and epidemiology of this disease.

show abstract

Novel epidemiological features of moyamoya disease

Cited by 388 publications

References 13 publications

Incidence and long‐term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Incidence and long‐term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan

Epidemiological Features of Moyamoya Disease in Japan

Review of Past Research and Current Concepts on the Etiology of Moyamoya Disease

Contact Info

Product

Resources

About