N‐terminal prohormone B‐type natriuretic peptide (NT‐proBNP) is an important biomarker of prognosis in heart failure and single valve disease. There are limited studies of complex valve disease. Patients with complex valve disease adopt a sedentary lifestyle, so symptoms may be difficult to detect. The authors aimed to determine whether NT‐proBNP correlates with the severity of the valve lesion and underlying cardiac function and whether resting NT‐proBNP predicts impaired peak VO2 in patients with complex valve disease. Forty‐five patients with complex moderate to severe stenosis or regurgitation of the heart valves underwent a clinical assessment, echocardiography, resting NT‐proBNP assessment, and formal cardiopulmonary exercise testing. In a multivariate analysis, the log NT‐proBNP (β=−9.3, SE=1.9, P<.0001) and lean body weight (β=0.59, SE=0.22, P=.01) were dominant independent predictors of peak VO2. An NT‐proBNP value of 84 pmol/L had 77% sensitivity and 70% specificity to predict impaired functional capacity, peak VO2 <60% (predicted), area under the curve=0.80. Resting NT‐proBNP was the best predictor of peak VO2 in patients with complex valve disease, while symptoms and ejection fraction are a less reliable guide.
Congest Heart Fail. 2010;16:50–54. © 2009 Wiley Periodicals, Inc.