Novel fabricated matrix via electrospinning for tissue engineering

Khil, Myung-Seob; Bhattarai, Shanta Raj; Kim, Hee Young; Kim, Sung Zoo; Lee, Keun Hyung

doi:10.1002/jbm.b.30122

Cited by 249 publications

(128 citation statements)

References 31 publications

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“…Self-assembled nanostructures are gaining attention in the fields of tissue engineering, drug delivery, sensing, catalysis and energy harvesting/storage [1][2][3][4][5][6][7][8]. In particular, nanofiber materials are of great interest because of their long length scales, resulting in very high aspect ratios, and the high degree of fiber orientation possible.…”

Section: Introductionmentioning

confidence: 99%

Hierarchically Structured Electrospun Fibers

Zander

2013

Polymers

130

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Abstract:Traditional electrospun nanofibers have a myriad of applications ranging from scaffolds for tissue engineering to components of biosensors and energy harvesting devices. The generally smooth one-dimensional structure of the fibers has stood as a limitation to several interesting novel applications. Control of fiber diameter, porosity and collector geometry will be briefly discussed, as will more traditional methods for controlling fiber morphology and fiber mat architecture. The remainder of the review will focus on new techniques to prepare hierarchically structured fibers. Fibers with hierarchical primary structures-including helical, buckled, and beads-on-a-string fibers, as well as fibers with secondary structures, such as nanopores, nanopillars, nanorods, and internally structured fibers and their applications-will be discussed. These new materials with helical/buckled morphology are expected to possess unique optical and mechanical properties with possible applications for negative refractive index materials, highly stretchable/high-tensile-strength materials, and components in microelectromechanical devices. Core-shell type fibers enable a much wider variety of materials to be electrospun and are expected to be widely applied in the sensing, drug delivery/controlled release fields, and in the encapsulation of live cells for biological applications. Materials with a hierarchical secondary structure are expected to provide new superhydrophobic and self-cleaning materials.

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Section: Introductionmentioning

confidence: 99%

Hierarchically Structured Electrospun Fibers

Zander

2013

Polymers

130

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“…Nanofiber scaffolds produced by electrospinning contain a large number of interconnected pores and fibers in the diameter of the extracellular matrix (ECM). 19 The ECM plays a pivotal role in controlling cell behaviors, such as adhesion, proliferation, migration, and differentiation. 20 Nanofibers can be produced from materials that are biocompatible and biodegradable, such as poly-ε-caprolactone (PCL), 21 poly(lactic-co-glycolic) acid (PLGA), 21 and chitosan.…”

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confidence: 99%

Significant improvement of biocompatibility of polypropylene mesh for incisional hernia repair by using poly-ε-caprolactone nanofibers functionalized with thrombocyte-rich solution

Plencner

Prosecká

Rampichová³

et al. 2015

IJN

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Incisional hernia is the most common postoperative complication, affecting up to 20% of patients after abdominal surgery. Insertion of a synthetic surgical mesh has become the standard of care in ventral hernia repair. However, the implementation of a mesh does not reduce the risk of recurrence and the onset of hernia recurrence is only delayed by 2–3 years. Nowadays, more than 100 surgical meshes are available on the market, with polypropylene the most widely used for ventral hernia repair. Nonetheless, the ideal mesh does not exist yet; it still needs to be developed. Polycaprolactone nanofibers appear to be a suitable material for different kinds of cells, including fibroblasts, chondrocytes, and mesenchymal stem cells. The aim of the study reported here was to develop a functionalized scaffold for ventral hernia regeneration. We prepared a novel composite scaffold based on a polypropylene surgical mesh functionalized with poly-ε-caprolactone (PCL) nanofibers and adhered thrombocytes as a natural source of growth factors. In extensive in vitro tests, we proved the biocompatibility of PCL nanofibers with adhered thrombocytes deposited on a polypropylene mesh. Compared with polypropylene mesh alone, this composite scaffold provided better adhesion, growth, metabolic activity, proliferation, and viability of mouse fibroblasts in all tests and was even better than a polypropylene mesh functionalized with PCL nanofibers. The gradual release of growth factors from biocompatible nanofiber-modified scaffolds seems to be a promising approach in tissue engineering and regenerative medicine.

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“…The main techniques to get continuous nanofiber bundles are described in Table 3. A liquid medium was used separately by Khil et al (Khil et al, 2005) and Smit et al (Smit et al, 2005)to collect nanofibers and subsequently wind into continuous nanofiber bundles (Table 3A). Nanofibers initially formed a random web on the liquid surface, which were drawn and lifted off with a rotating mandrel to form a fiber bundle.…”

Section: Continuous Nanofiber Bundlesmentioning

confidence: 99%

“…The typical rectifying current-voltage characteristics of the yarn have potential for constructing sensors and transistor devices. A plain woven fabric of PCL nanofibers has been shown successful for cell cultures, and used as a woven tissue scaffold (Khil et al, 2005). Another application for yarns is composite reinforcement, to enhance the fracture toughness and damage tolerance.…”

Section: Potential Applicationsmentioning

confidence: 99%