Novel fabricated potentiometric sensors for selective determination of carbinoxamine with different greenness evaluation perspectives

Soliman, Rabab M.; Rostom, Yasmin; Mahmoud, Amr M.; Fayez, Yasmin M.; Mostafa, Nadia M.; Monir, Hany H.

doi:10.1016/j.microc.2022.108381

Cited by 20 publications

(5 citation statements)

References 60 publications

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“…51,52 Assessing the environmental impact of various analytical procedures is essential to ensure they align with the principles of Green Analytical Chemistry (GAC). 53,54 To facilitate this, several evaluation tools, known as "green metrics," have been developed. These metrics allow for the quantitative or qualitative assessment of an analytical technique's environmental sustainability.…”

Section: Resultsmentioning

confidence: 99%

Novel Green Screen-Printed Potentiometric Sensor for Monitoring Antihistamine Drug Chlorphenoxamine HCl in Various Matrices

Ashraf,

El-Zeany,

Sedik

et al. 2024

J. Electrochem. Soc.

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The pharmaceutical sector is seeking cost-effective analyzers that deliver precise, real-time data. This study aims to establish a correlation between the pharmaceutical industry and advancements in solid-contact ion-selective electrodes for quantifying chlorphenoxamine hydrochloride (CPX) concentration in various matrices. A comparative analysis of the performance between solid contact and liquid contact sensors showed that solid contact sensors outperformed their liquid contact counterparts in terms of durability, handling, and ease of integration. A sensor was developed using MWCNT and calix[8]arene as ionophore, resulting in a Nernstian potentiometric response for CPX across a linear range of 5.0×10−5 to 1.0×10−8 M. The slope of the response was 57.89 ± 0.77 mV/decade, and the standard potential was determined to be 371.9 ± 0.8 mV. The developed sensor exhibits notable intrinsic advantages, such as a rapid response time of 12 ± 2 seconds and an extended lifespan of 3 months. The sensor exhibiting optimal performance has been effectively employed for the analysis of CPX in different matrices, including pharmaceutical formulations, urine, and plasma. The developed method underwent validation in compliance with ICH requirements. Finally, the method’s greenness and whiteness were evaluated using five different tools and successfully compared to those obtained from the established reported method.

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Section: Resultsmentioning

confidence: 99%

Novel Green Screen-Printed Potentiometric Sensor for Monitoring Antihistamine Drug Chlorphenoxamine HCl in Various Matrices

Ashraf,

El-Zeany,

Sedik

et al. 2024

J. Electrochem. Soc.

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“…Applying various assessment techniques to compare the proposed methods' levels of greenness allowed for the method's greenness to be evaluated. Analytical Eco-Scale [31] is a semi-quantitative approach that operates on the method's penalty points (PP) minus 100. National Environmental Methods Index (NEMI) [32] is a circular NEMI pictogram, consisting of four quadrants coded with green if they meet the requirements.…”

Section: Greenness Profile Assessmentmentioning

confidence: 99%

A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

El Fiky,

Abd El Ghany,

Badawey

et al. 2024

Futur J Pharm Sci

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Background Carivalan® dosage form containing carvedilol and ivabradine is widely indicated for patients with stable angina. Three precise, eco-friendly and reproducible spectrophotometric techniques were created for resolving the researched drugs in their mixtures using zero and/or ratio spectra. Technique I is a factorized dual wavelength coupled with spectrum subtraction (FDW-SS), technique II is a ratio difference, and technique III is a constant center coupled with spectrum subtraction (CC-SS). Moreover, CAR and IVA were simultaneously determined in the existence of their oxidative degradation products exploiting the newly developed induced tripartite amplitude difference coupled with ratio subtraction (ITAD-RS) technique. Results The calibration curves for CAR and IVA showed linearity within 3.0–30.0 µg/ml, each. Techniques' precision, accuracy, and linearity ranges were resolved and validated in harmony with ICH guidelines. Additionally, the specificity was examined by examining created combinations of the proposed drugs with LOD of 0.258 and 0.290 for CAR, while for IVA 0.272 and 0.204. Conclusion These techniques were used to determine the presence of the provided drugs in Carivalan® tablets. There is statistical comparison between the found results of the offered spectrophotometric techniques and the previously reported ones with no discernible variance in the acquired results.

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“…To enhance electrical signal stability of SC-ISEs many ion-toelectron transducers have been introduced such as solidcontact functional materials for instance; conductive polymers (CPs), [16][17][18][19][20] and nanomaterials. [21][22][23][24][25][26][27] Addition of these materials improved sensors robustness and reliability, while being calibrated and maintenance free. In comparison to the classical liquid contact, SC-ISEs polymeric membrane achieved the following properties; they become easier in design, more exible and compatible with modern 3D printing and can be miniaturized.…”

Section: Introductionmentioning

confidence: 99%

Novel solid-contact ion-selective electrode based on a polyaniline transducer layer for determination of alcaftadine in biological fluid

et al. 2023

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Novel fabricated potentiometric sensors for selective determination of carbinoxamine with different greenness evaluation perspectives

Cited by 20 publications

References 60 publications

Novel Green Screen-Printed Potentiometric Sensor for Monitoring Antihistamine Drug Chlorphenoxamine HCl in Various Matrices

Novel Green Screen-Printed Potentiometric Sensor for Monitoring Antihistamine Drug Chlorphenoxamine HCl in Various Matrices

A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

Novel solid-contact ion-selective electrode based on a polyaniline transducer layer for determination of alcaftadine in biological fluid

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