Novel findings for quercetin encapsulation and preservation with cyclodextrins, liposomes, and drug-in-cyclodextrin-in-liposomes

Azzi, Joyce; Jraij, Alia; Auezova, Lizette; Fourmentin, Sophie; Greige‐Gerges, Hélène

doi:10.1016/j.foodhyd.2018.03.006

Cited by 93 publications

(44 citation statements)

References 83 publications

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“…In the fields of pharmacy, medicine, and nutrition, there are several macrocycle molecules that have been used for improving the solubility of the active ingredient of drugs and their stability and bioavailability for the determination of proteins and nucleic acids. They have even exhibited biological activity or value in sensitization therapies, as seen for example with cucurbit[ n ]urils [1], macrocyclic tetrapyrazolics [2], resorcinarenes [3], crown ethers [4], cyclodextrins [5], phthalocyanines [6], and calixarenes [7], among others. All of this has been possible due to the fact that these compounds are able to form a complex with molecules of biological interest such as antibiotics [1], proteins and nucleic acids [4], food nutraceuticals [5], and cholesterol [7], among many other compounds.…”

Section: Introductionmentioning

confidence: 99%

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

2019

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The properties and characteristics of calix[n]arenes are described, as well as their capacity to form amphiphilic assemblies by means of the design of synthetic macrocycles with a hydrophilic head and a hydrophobic tail. Their interaction with various substances of interest in pharmacy, engineering, and medicine is also described. In particular, the role of the calix[n]arenes in the detection of dopamine, the design of vesicles and liposomes employed in the manufacture of systems of controlled release drugs used in the treatment of cancer, and their role in improving the solubility of testosterone and anthelmintic drugs and the biocompatibility of biomaterials useful for the manufacture of synthetic organs is emphasized. The versatility of these macrocycles, able to vary in size, shape, functional groups, and hydrophobicity and to recognize various biomolecules and molecules with biological activity without causing cytotoxicity is highlighted.

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Section: Introductionmentioning

confidence: 99%

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

2019

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“…DCL–DL is also being investigated for loading substances to be used as additives for providing the photoprotection and preservation of essential oils [26] or food nutraceuticals [27,28].…”

Section: Introductionmentioning

confidence: 99%

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release

et al. 2018

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In this study, the encapsulation of curcumin (Cur) in “drug-in-cyclodextrin-in-liposomes (DCL)” by following the double-loading technique (DL) was proposed, giving rise to DCL–DL. The aim was to analyze the effect of cyclodextrin (CD) on the physicochemical, stability, and drug-release properties of liposomes. After selecting didodecyldimethylammonium bromide (DDAB) as the cationic lipid, DCL–DL was formulated by adding 2-hydroxypropyl-α/β/γ-CD (HPβCD)–Cur complexes into the aqueous phase. A competitive effect of cholesterol (Cho) for the CD cavity was found, so cholesteryl hemisuccinate (Chems) was used. The optimal composition of the DCL–DL bilayer was obtained by applying Taguchi methodology and regression analysis. Vesicles showed a lower drug encapsulation efficiency compared to conventional liposomes (CL) and CL containing HPβCD in the aqueous phase. However, the presence of HPβCD significantly increased vesicle deformability and Cur antioxidant activity over time. In addition, drug release profiles showed a sustained release after an initial burst effect, fitting to the Korsmeyer-Peppas kinetic model. Moreover, a direct correlation between the area under the curve (AUC) of dissolution profiles and flexibility of liposomes was obtained. It can be concluded that these “drug-in-cyclodextrin-in-deformable” liposomes in the presence of HPβCD may be a promising carrier for increasing the entrapment efficiency and stability of Cur without compromising the integrity of the liposome bilayer.

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“…In order to enhance the characteristics of quercetin, liposomes of cyclodextrin and β-lactoglobulin have been employed for its encapsulation. AFM was used to observe the structure of this emulsion system and its surface characteristics, thus guiding the optimization of process parameters and the evaluation and adjustment of product properties (Azzi, Jraij, Auezova, Fourmentin, & Greige-Gerges, 2018;Chavoshpour-Natanzi, & Sahihi, 2019). In addition, some researchers developed a new multilayer microcapsule, and used AFM to monitor the performance of the product (Ansarifar, Mohebbi, Shahidi, Koocheki, & Ramezanian, 2017).…”

Section: Food Engineering Materialsmentioning

confidence: 99%

Investigation of food microstructure and texture using atomic force microscopy: A review

Wen

Liu

et al. 2020

Comp Rev Food Sci Food Safe

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We review recent applications of atomic force microscopy (AFM) to characterize microstructural and textural properties of food materials. Based on interaction between probe and sample, AFM can image in three dimensions with nanoscale resolution especially in the vertical orientation. When the scanning probe is used as an indenter, mechanical features such as stiffness and elasticity can be analyzed. The linkage between structure and texture can thus be elucidated, providing the basis for many further future applications of AFM. Microstructure of simple systems such as polysaccharides, proteins, or lipids separately, as characterized by AFM, is discussed. Interaction of component mixtures gives rise to novel properties in complex food systems due to development of structure. AFM has been used to explore the morphological characteristics of such complexes and to investigate the effect of such characteristics on properties. Based on insights from such investigations, development of food products and manufacturing can be facilitated. Mechanical analysis is often carried out to evaluate the suitability of natural or artificial materials in food formulations. The textural properties of cellular tissues, food colloids, and biodegradable films can all be explored at nanometer scale, leading to the potential to connect texture to this fine structural level. More profound understanding of natural food materials will enable new classes of fabricated food products to be developed.

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Novel findings for quercetin encapsulation and preservation with cyclodextrins, liposomes, and drug-in-cyclodextrin-in-liposomes

Cited by 93 publications

References 83 publications

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

Calixarenes: Generalities and Their Role in Improving the Solubility, Biocompatibility, Stability, Bioavailability, Detection, and Transport of Biomolecules

Novel Findings about Double-Loaded Curcumin-in-HPβcyclodextrin-in Liposomes: Effects on the Lipid Bilayer and Drug Release

Investigation of food microstructure and texture using atomic force microscopy: A review

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