2020
DOI: 10.1080/10408398.2020.1770199
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Novel findings of the association between gut microbiota–derived metabolite trimethylamine N-oxide and inflammation: results from a systematic review and dose-response meta-analysis

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Cited by 46 publications
(26 citation statements)
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“…Inflammation, oxidative stress and DNA damage could be potential molecular mechanisms between TMAO and carcinogenesis. Recently, a dose-response meta-analysis summarized the results of studies on the relationship between circulating TMAO concentrations and inflammation risk, and then revealed a non-linear positive association between increased TMAO concentrations and C-reactive protein (68). Yue et al demonstrated that TMAO could trigger the activation of the nodlike receptor family pyrin domain containing 3 (NLRP3) inflammasome and inhibit the autophagy gene ATG16L1induced autophagy to promote the progression of inflammatory bowel disease (IBD) (69).…”
Section: Tmao and Crcmentioning
confidence: 99%
See 1 more Smart Citation
“…Inflammation, oxidative stress and DNA damage could be potential molecular mechanisms between TMAO and carcinogenesis. Recently, a dose-response meta-analysis summarized the results of studies on the relationship between circulating TMAO concentrations and inflammation risk, and then revealed a non-linear positive association between increased TMAO concentrations and C-reactive protein (68). Yue et al demonstrated that TMAO could trigger the activation of the nodlike receptor family pyrin domain containing 3 (NLRP3) inflammasome and inhibit the autophagy gene ATG16L1induced autophagy to promote the progression of inflammatory bowel disease (IBD) (69).…”
Section: Tmao and Crcmentioning
confidence: 99%
“…Inflammation, oxidative stress and DNA damage could be potential molecular mechanisms between TMAO and carcinogenesis. Recently, a dose-response meta-analysis summarized the results of studies on the relationship between circulating TMAO concentrations and inflammation risk, and then revealed a non-linear positive association between increased TMAO concentrations and C-reactive protein ( 68 ). Yue et al.…”
Section: Detrimental Microbiota-derived Metabolites In Intestinal Carcinogenesismentioning
confidence: 99%
“…Some dietary nutrients such as L-carnitine, phosphatidylcholine and choline are especially processed by intestinal bacteria to produce trimethylamine (TMA), which is absorbed by the intestine and converted into trimethylamine-N-Oxide (TMAO) in the liver by flavin-containing monooxygenase 3 [12][13][14]. It has been demonstrated that there is a positive association between high TMAO concentration and adverse health outcomes such as obesity, inflammation, cardiovascular events and total mortality [9,[15][16][17][18][19]. Several studies have proposed a possible relationship between TMAO and stroke risk, but their results are controversial [7,20,21].…”
Section: Introductionmentioning
confidence: 99%
“…It is important to understand which foods or which other nutritional strategies (e.g., cooking method or selective microbiome intervention) have a greater effect on plasma TMAO levels, as this would allow for better nutritional prescribing, particularly in patients with modestly impaired renal function [ 9 ] and type-2 diabetes mellitus (T2DM) [ 46 ] (in which TMAO has been demonstrated to have even more deleterious effects on CVD risk). Some authors have proposed that a simpler method of reducing TMAO might be to eat fewer foods containing TMA precursors and increase those that favour non-TMA-producing bacteria (e.g., vegetables/fruit) or suppression of FMO3 activity (e.g., vegetables containing indole) [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…Compelling evidence suggests that circulating TMAO may promote atherosclerosis by altering the clearance of cholesterol in the liver, promoting inflammation and oxidation of LDL cholesterol by up-regulation of the macrophage scavenger and foam cell formation [ 7 ]. The current literature shows that TMAO may be a major risk factor for cardiovascular disease (CVD), especially in individuals who have already had a cardiovascular event or have a kidney disease [ 8 , 9 ].…”
Section: Introductionmentioning
confidence: 99%