Novel Flow Quantification of the Carotid Bulb and the Common Carotid Artery with Vector Flow Ultrasound

Pedersen, Michael Ingemann; Pihl, Michael Johannes; Haugaard, Per; Hansen, Kristoffer Lindskov; Lange, Theis; Lönn, Lars; Nielsen, Michael Bachmann; Jensen, Jørgen Arendt

doi:10.1016/j.ultrasmedbio.2014.06.001

Cited by 53 publications

(63 citation statements)

References 24 publications

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“…Velocity decreased with flow separation phenomenon, which occurred when the vascular cross-sectional area expanded rapidly. This finding was consistent with the previous studies (MORBIDUCCI; PONZINI et al, 2011;PEDERSEN;PIHL et al, 2014). With low velocity accompanied with vortex, the elements in the flood like platelet and lipid were prone to separate out and induced the formation of atherosclerosis in the local wall (FAN;SAKAI et al, 2010).…”

Section: Resultssupporting

confidence: 93%

Assessment of hemodynamic parameters distribution in normal carotid artery by using computational fluid dynamics based on CE-MRA data

Xiao¹,

Sun²,

Suo³

et al. 2018

Biosci. J.

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ABSTRACT:This study was to analyze the in vivo distribution of wall shear stress (WSS), velocity and inplane pressure difference in normal carotid artery by using computational fluid dynamics (CFD) based on contrastenhanced MRA (CE-MRA) data and to determine whether there were differences in these hemodynamic parameters between atherosclerosis-free and atherosclerosis-prone areas. CE-MRA was performed on 16 normal carotid arteries to obtain carotid three-dimensional surface data. CFD analysis was then performed to estimate those parameters in atherosclerosis-free (distal common carotid artery and distal internal carotid artery) and atherosclerosis-prone (carotid bifurcation) areas. One-way analysis of variance (ANOVA) was conducted to analyze differences among these three areas. CFD analysis revealed that WSS and velocity were significantly lower in carotid bifurcation compared to distal common carotid artery (CCA) (P =0.011, P <0.001, respectively) and distal internal carotid artery (ICA) (P <0.001, P <0.001, respectively). While in-plane pressure difference was significantly higher in carotid bifurcation compared to distal CCA (P <0.001) and distal ICA (P =0.005). Hemodynamic environment in carotid bifurcation of normal carotid artery which assessed by using CFD analysis appeared to be with lower WSS and lower velocity, while with higher in-plane pressure difference. These characterizations might facilitate the initiation of atherosclerosis.

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Section: Resultssupporting

confidence: 93%

Assessment of hemodynamic parameters distribution in normal carotid artery by using computational fluid dynamics based on CE-MRA data

Xiao¹,

Sun²,

Suo³

et al. 2018

Biosci. J.

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“…The performance can also be affected by various artifacts because of aliasing and beam-flow angle variations (Evans and Wells 2010). Some new Doppler techniques have been developed, including crossed-beam vector Doppler (Kripfgans et al 2006;Pastorelli et al 2008;Ricci et al 2014;Tortoli et al 2010), vector flow mapping (Ohtsuki and Tanaka 2006;Uejima et al 2010), directional cross-correlation method (Jensen and Lacasa 1999;Kortbek and Jensen 2006), transverse oscillation method (Pedersen et al 2014;Udesen and Jensen 2006), and pulse inversion Doppler (Simpson et al 1999;Tremblay-Darveau et al 2014). Non-Doppler ultrasound techniques have also been investigated.…”

Section: Introductionmentioning

confidence: 99%

Flow Velocity Mapping Using Contrast Enhanced High-Frame-Rate Plane Wave Ultrasound and Image Tracking: Methods and Initial in Vitro and in Vivo Evaluation

Leow

Bazigou

Eckersley

et al. 2015

Ultrasound in Medicine & Biology

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Ultrasound imaging is the most widely used method for visualising and quantifying blood flow in medical practice, but existing techniques have various limitations in terms of imaging sensitivity, field of view, flow angle dependence, and imaging depth. In this study, we developed an ultrasound imaging velocimetry approach capable of visualising and quantifying dynamic flow, by combining high-frame-rate plane wave ultrasound imaging, microbubble contrast agents, pulse inversion contrast imaging and speckle image tracking algorithms. The system was initially evaluated in vitro on both straight and carotid-mimicking vessels with steady and pulsatile flows and in vivo in the rabbit aorta. Colour and spectral Doppler measurements were also made. Initial flow mapping results were compared with theoretical prediction and reference Doppler measurements and indicate the potential of the new system as a highly sensitive, accurate, angle-independent and full field-of-view velocity mapping tool capable of tracking and quantifying fast and dynamic flows.

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“…Several studies have been realized with TO, examining the advantages and limitations of the method [6][7][8][9][10]. Furthermore, preliminary results have been published on cardiac flow using intraoperative TO [11,12].…”

Section: Introductionmentioning

confidence: 99%

Vector flow imaging of the ascending aorta

Hansen

Møller‐Sørensen

Kjærgaard

et al. 2015

2015 IEEE International Ultrasonics Symposium (IUS)

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Abstract-In the ascending aorta, atherosclerotic plaque formation, which is a risk factor for cerebrovascular events, most often occurs along the inner curvature. Atherosclerosis is a multifactorial disease, but the predilection site for the aortic vessel degradation is probably flow dependent. To better understand the aortic flow and especially the complex flow patterns, the ascending aorta was scanned intraoperatively in patients undergoing heart surgery using the angle-independent vector velocity ultrasound method Transverse Oscillation (TO). The primary aim of the study was to analyze systolic backflow in relation to atherosclerosis. Thirteen patients with normal aortic valves were included in to the study. TO implemented on a conventional US scanner (ProFocus 2202 UltraView, BK Medical, Herlev, Denmark) with a linear array transducer (8670, BK Medical, Herlev, Denmark) was used intraoperatively on the ascending aorta in long axis view. The presence of systolic backflow, visualized with TO, was correlated to aortic atherosclerosis, to systolic velocities obtained with transesophageal echocardiography and cardiac output obtained with pulmonary artery catheter thermodilution, to gender, age, aortic diameter, left ventricular ejection fraction (LVEF) and previous myocardial infarctions (MI). Systolic backflow in the ascending aorta was present for 38% (n=5) of the patients. The location of the backflow was strongly associated to the location of the plaques (p<0.005), and backflow was associated to high systolic velocities (p<0.05). The other obtained parameters were not associated to systolic backflow. It was shown that systolic backflow is a common flow feature in the ascending aorta, and that backflow is associated to atherosclerotic plaques and systolic velocities. The study indicates that vector flow imaging using TO can provide important blood flow information in the assessment of atherosclerosis.

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Novel Flow Quantification of the Carotid Bulb and the Common Carotid Artery with Vector Flow Ultrasound

Cited by 53 publications

References 24 publications

Assessment of hemodynamic parameters distribution in normal carotid artery by using computational fluid dynamics based on CE-MRA data

Assessment of hemodynamic parameters distribution in normal carotid artery by using computational fluid dynamics based on CE-MRA data

Flow Velocity Mapping Using Contrast Enhanced High-Frame-Rate Plane Wave Ultrasound and Image Tracking: Methods and Initial in Vitro and in Vivo Evaluation

Vector flow imaging of the ascending aorta

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