Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study

Abstract

Synthesis of flurbiprofen based oxadiazole derivatives as potent urease inhibitors.

Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach

“…The clinical value of heterocyclic compounds captures interest in the synthesis of novel compounds and the investigation of their pharmacological characteristics. [6][7][8] Medicinal chemists are unceasingly working to discover the pharmacological potential of heterocycles in which benzothiazoles are stimulating forecasts. [9] It has been established that the endocyclic sulfur and nitrogen activities in the heterocyclic nucleus are essential for various biological activities.…”

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α‐glucosidase Inhibition, Molecular Docking and DFT Simulation Approach

“…[33] Likewise, Momin et al, reported the synthesis with α-amylase inhibitory activity of flurbiprofen based oxadiazoles, [19] while Sajjad with his team members reported the synthesis and urease inhibition activity of novel derivatives with excellent results. [18,34] Inaddition, our group have reported the synthesis, α-glucosidase inhibition, [21] analgesic and anti-inflammatory activities [35] of novel derivatives of the drug flurbiprofen.…”

Unveiling potent Schiff base derivatives with selective xanthine oxidase inhibition: In silico and in vitro approach

“…Quantum chemistry calculations were performed to gain a better understanding of the molecular geometry and electronic properties of the most active molecules. The density functional theory (DFT) method conjugated to the 6-311G(d,p) basis set was used for all calculations using Gaussian 09 software ( Ahmad et al, 2023a , Ahmad et al, 2023b , Frisch et al, 2009 ). The absence of imaginary frequencies was checked to confirm the fundamental states.…”