Novel folated Pluronic/poly(lactic acid) nanoparticles for targeted delivery of paclitaxel

Xiong, Xiang‐Yuan; Long, Tao; Qin, Xiang; Li, Zi Ling; Gong, Yan; Li, Yu Ping; Yang, Yi; Liu, Zhi Yong

doi:10.1039/c6ra09271c

Cited by 16 publications

(9 citation statements)

References 44 publications

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“…Xiong et al (2016) synthesized a block copolymer containing folic acid, pluronic (a polyethylene oxide-poly propylene oxide-polyethylene oxide block copolymer) and lactic acid. Resulting product was employed to produce paclitaxel-loaded nanoparticles.…”

Section: The New Paradigm Introduced By Nanoparticlesmentioning

confidence: 99%

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Casalini

Rossi

Castrovinci

et al. 2019

Front. Bioeng. Biotechnol.

367

181

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Polylactic acid (PLA)—based polymers are ubiquitous in the biomedical field thanks to their combination of attractive peculiarities: biocompatibility (degradation products do not elicit critical responses and are easily metabolized by the body), hydrolytic degradation in situ, tailorable properties, and well-established processing technologies. This led to the development of several applications, such as bone fixation screws, bioresorbable suture threads, and stent coating, just to name a few. Nanomedicine could not be unconcerned by PLA-based materials as well, where their use for the synthesis of nanocarriers for the targeted delivery of hydrophobic drugs emerged as a new promising application. The purpose of the here presented review is two-fold: on one side, it aims at providing a broad overview of PLA-based materials and their properties, which allow them gaining a leading role in the biomedical field; on the other side, it offers a specific focus on their recent use in nanomedicine, highlighting opportunities and perspectives.

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Section: The New Paradigm Introduced By Nanoparticlesmentioning

confidence: 99%

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Casalini

Rossi

Castrovinci

et al. 2019

Front. Bioeng. Biotechnol.

367

181

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“…The cumulative release amount of PTX loaded in FA‐F127‐PCL and PCL‐F127‐PCL nanoparticles was 8.0% and 8.1%, respectively. It was noticed that the cumulative release amount of PTX from all four kinds of nanoparticles was pretty low, which was lower than that from FA‐Pluronic‐PLA copolymers we studied previously . This could be because the degrading speed of PCL block was much lower than that of PLA block.…”

Section: Resultsmentioning

confidence: 69%

“…FA ligands have been conjugated to Pluronic/polylactide and Pluronic/poly(lactide‐ co ‐glycolide) block copolymers previously by our groups. The FA‐conjugated nanoparticles show good targeting properties over tumor cells …”

Section: Introductionmentioning

confidence: 99%

Effect of the Folate Ligand Density on the Targeting Property of Folated‐Conjugated Polymeric Nanoparticles

Gong

Xiong

et al. 2018

Macromolecular Bioscience

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Targeted drug delivery systems have attracted increasing attention due to their ability for delivering anticancer drugs selectively to tumor cells. Folic acid (FA)‐conjugated targeted block copolymers, FA‐Pluronic‐polycaprolactone (FA‐Pluronic‐PCL) are synthesized in this study. The anticancer drug paclitaxel (PTX) is loaded in FA‐Pluronic‐PCL nanoparticles by nanoprecipitation method. The in vitro release of PTX from FA‐Pluronic‐PCL nanoparticles shows slow and sustained release behaviors. The effect of FA ligand density of FA‐Pluronic‐PCL nanoparticles on their targeting properties is examined by both cytotoxicity and fluorescence methods. It is shown that FA‐Pluronic‐PCL nanoparticles indicated better targeting ability than non‐targeted PCL‐Pluronic‐PCL nanoparticles. Furthermore, FA‐F127‐PCL nanoparticle with 10% FA molar content has more effective antitumor activity and higher cellular uptake than those with 50% and 91% FA molar content. These results prove that FA‐F127‐PCL nanoparticle with 10% FA molar content can be a better candidate as the drug carrier in targeted drug delivery systems.

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“…Functionalization improved cellular uptake and nanoparticles proved to enhance the therapeutic effect of the drug reducing side effects. Xiong et al (2016) synthesized a block copolymer containing folic acid, pluronic (a polyethylene oxide-poly propylene oxide-polyethylene oxide block copolymer) and lactic acid. Resulting product was employed to produce paclitaxel-loaded nanoparticles.…”

Section: Stabilizer Concentrationmentioning

confidence: 99%

Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts

2020

Frontiers Research Topics

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The compilation of articles constituting this eBook is the property of Frontiers.Each article within this eBook, and the eBook itself, are published under the most recent version of the Creative Commons CC-BY licence.The version current at the date of publication of this eBook is CC-BY 4.0. If the CC-BY licence is updated, the licence granted by Frontiers is automatically updated to the new version.When exercising any right under the CC-BY licence, Frontiers must be attributed as the original publisher of the article or eBook, as applicable.Authors have the responsibility of ensuring that any graphics or other materials which are the property of others may be included in the CC-BY licence, but this should be checked before relying on the CC-BY licence to reproduce those materials. Any copyright notices relating to those materials must be complied with.Copyright and source acknowledgement notices may not be removed and must be displayed in any copy, derivative work or partial copy which includes the elements in question.

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Novel folated Pluronic/poly(lactic acid) nanoparticles for targeted delivery of paclitaxel

Abstract: In vivo prolonged circulation time and enhanced tumor resistant ability of targeted PTX-loaded FA–Pluronic–PLA nanoparticles.

Cited by 16 publications

References 44 publications

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications

Effect of the Folate Ligand Density on the Targeting Property of Folated‐Conjugated Polymeric Nanoparticles

Polymeric Nano-Biomaterials for Medical Applications: Advancements in Developing and Implementation Considering Safety-By-Design Concepts

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