Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models

Wróblewska, K.; Milanowski, Bartłomiej; Kucińska, Małgorzata; Plewa, Szymon; Długaszewska, Jolanta; Muszalska-Kolos, Izabela

doi:10.3390/ph14090849

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…Moreover, common peaks between the spectra of [Ch]Sa and [Ch]Cit were found at ∼3200 cm −1 , caused by the O−H stretching of choline, at ∼1400 cm −1 , due to the presence of ammonium methyl groups, and at ∼1000 cm −1 , originating from the C−O stretch of choline. These observations agree with experimental FTIR spectra from the literature for [Ch]Sa, 54,55 confirming the chemical structure of the synthesized API-IL. When making these comparisons, it must be taken into consideration that only the position of the peaks from DFT predictions can be compared with the experimental spectra, not the intensity or width of the peak.…”

Section: Api Immobilizationsupporting

confidence: 89%

Extraction of Salicylic Acid Using Sustainable ATPSs and Respective Immobilization as API-IL at Small Pilot Scale

Velho,

Sousa,

Macedo

2024

J. Chem. Eng. Data

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Active pharmaceutical ingredients (APIs), a class of emerging pollutants present in residual waters, are often found in hospital effluents and are known to pose profound consequences to aquatic environments, such as the feminization of fish, for which finding sustainable extractive methodologies for these chemical species is a must. Aqueous two-phase systems (ATPSs) constitute a liquid− liquid extraction technique with low environmental impact that often results in the use of a salting-out agent, such as tripotassium citrate (K 3 Citrate), to separate two otherwise miscible phases. To increase the solubility of the extracted active pharmaceutical ingredients while preserving their specific properties, one can immobilize them as novel ionic liquids (ILs), and these complex chemical compounds are known as active pharmaceutical ingredients-ionic liquids (API-ILs). In this work, salicylic acid (Sa), a pharmaceutical component with wide medical and industrial applications, was extracted in ATPSs and immobilized as cholinium salicylate. Specifically, the systems {ethyl lactate (1) + Na 3 Citrate or K 3 Citrate or Na 2 Tartrate or NaKTartrate or Na 2 Succinate (2) + water (3)} were used at 298.15 K and 0.1 MPa. To advance large-scale application, the extraction studies were performed at small pilot scale using 500 g of ATPS and with the compositions of the shortest and longest tie-lines, having obtained the largest partition coefficient (K = (10 ± 2) × 10 1 ) and extraction efficiency (E/ % = 98.2 ± 0.7%) for the longest tie-lines of the ATPSs based on K 3 Citrate and Na 2 Tartrate, respectively. Then, the ATPS based on K 3 Citrate was used to immobilize salicylic acid, and the structures of the synthesized ionic liquids (cholinium salicylate and cholinium citrate) were validated using FTIR measurements and IR predictions from computational chemistry.

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Section: Api Immobilizationsupporting

confidence: 89%

Extraction of Salicylic Acid Using Sustainable ATPSs and Respective Immobilization as API-IL at Small Pilot Scale

Velho,

Sousa,

Macedo

2024

J. Chem. Eng. Data

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“…Therefore, it is generally combined with other polymers to improve the properties of the carrier [ 14 , 111 ] and applied in different concentrations (0.5–2.0% w / w , 30–50% w / w ) HA is characterized by high molecular weight, up to 10MDa, and is capable of water binding. Due to its unique properties, it can be used as an active ingredient in formulations, e.g., as an agent with regenerating properties in eye drops [ 112 ]. It is often used as a factor to improve the condition of the skin.…”

Section: Other Polysaccharidesmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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“…Undoubtedly, no other organ of the body, beside the skin, is so readily available or so easy to observe. However, due to the unique properties, there are specific opportunities but also difficulties in administering drugs to the eye [33]. Ophthalmic preparations represent an obvious alternative to the oral forms, which have many limitations such as low bioavailability due to hepatic circulation and potential food interactions, delayed onset of action, and systemic side-effects [34][35][36].…”

Section: Review 1 Introductionmentioning

confidence: 99%

Microneedle-based ocular drug delivery systems – recent advances and challenges

Gadziński¹,

Froelich²,

Wojtyłko³

et al. 2022

Beilstein J. Nanotechnol.

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Eye diseases and injuries constitute a significant clinical problem worldwide. Safe and effective delivery of drugs to the eye is challenging mostly due to the presence of ocular barriers and clearance mechanisms. In everyday practice, the traditional eye drops, gels and ointments are most often used. Unfortunately, they are usually not well tolerated by patients due to the need for frequent use as well as the discomfort during application. Therefore, novel drug delivery systems with improved biopharmaceutical properties are a subject of ongoing scientific investigations. Due to the developments in microtechnology, in recent years, there has been a remarkable advance in the development of microneedle-based systems as an alternative, non-invasive form for administering drugs to the eye. This review summarizes the latest achievements in the field of obtaining microneedle ocular patches. In the manuscript, the most important manufacturing technologies, microneedle classification, and the research studies related to ophthalmic application of microneedles are presented. Finally, the most important advantages and drawbacks, as well as potential challenges related to the unique anatomy and physiology of the eye are summarized and discussed.

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Novel Formulation of Eye Drops Containing Choline Salicylate and Hyaluronic Acid: Stability, Permeability, and Cytotoxicity Studies Using Alternative Ex Vivo and In Vitro Models

Cited by 3 publications

References 47 publications

Extraction of Salicylic Acid Using Sustainable ATPSs and Respective Immobilization as API-IL at Small Pilot Scale

Extraction of Salicylic Acid Using Sustainable ATPSs and Respective Immobilization as API-IL at Small Pilot Scale

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Microneedle-based ocular drug delivery systems – recent advances and challenges

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