Novel formulation of uncoated enteric capsule shells: Study the effect of gelling agents and salts on the rheology and physical properties

Kalmer, Ramin Ramezani; Karimi, Afzal; Moosavi, Seyedehmaryam; Ghanbari, Mojgan; Sadjadinia, Atefeh; Samandarian, Dariush; Ramezanalizadeh, Hamed; Gholizadeh dogaheh, Samira

doi:10.1016/j.matchemphys.2023.128614

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…6d). After a while, the G′ improves quicker than the G′′, which indicates that the solution phase has changed into a soft-solid gel with the best elastic behavior [45,44]. The setting time was obtained at 21 s for the modulus diagram against time at 40.1°C (temperature gelation).…”

Section: Rheological Behaviorsmentioning

confidence: 99%

Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug-released behavior of novel Eudragit L100-55/gelatin gastro-resistance uncoated capsule

Kalmer,

Karimi,

Dogaheh

et al. 2024

Polym. Bull.

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Capsules have been investigated as a popular oral dosage form among communities due to their simplicity and ease of production. Capsules that are considered in the gastro-resistance category can be very bene cial due to enhanced drug absorption, improved stability, targeted release, etc. This study investigated the effect of enteric polymers on uncoated hard capsule fabrication and dissolution properties. The polymers used in this study included HPMCPh and Eudragit L100-55. Eight different formulations based on HPMCPh, Eudragit, and gelatin were examined to identify the ideal formulation for the product of uncoated enteric hard capsules with preferred physicochemical and gastro-resistance properties. The results reveal that the capsules containing Eudragit (F1), HPMCPh (F2), Eudragit/HPMCPh/gelatin (F3), and Eudragit/gelatin (F4) are steady within the simulated stomach environment, and drug release does not occur for 120 minutes. The outcomes demonstrate that, among the proposed formulas, the F4 formula is suitable both in terms of capsulation form and delayed release properties and shows no microbial growth. The properties of the optimized sample were studied by FTIR, FESEM, tensile strength, humidity, and rheology. The results illustrated that gelatin-based hydrogels with Eudragit (F4) are potential candidates for manufacturing uncoated enteric hard capsules that inhibit drug release in a gastric pH medium and act as a pH-sensitive drug release system.

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Section: Rheological Behaviorsmentioning

confidence: 99%

Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug-released behavior of novel Eudragit L100-55/gelatin gastro-resistance uncoated capsule

Kalmer,

Karimi,

Dogaheh

et al. 2024

Polym. Bull.

Self Cite

View full text Add to dashboard Cite

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Capsule-forming polymers

Bandi,

Datta,

Parambath

2025

Polymers for Oral Drug Delivery Technologies

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Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug released behavior of novel Eudragit L100-55/ gelatin gastro-resistance uncoated capsule

Kalmer,

Karimi,

Dogaheh

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Capsules have been investigated as a popular oral dosage form among communities due to their simplicity and ease of production. Capsules that are considered in the gastro-resistance category can be very beneficial due to enhanced drug absorption, improved stability, targeted release, etc. This study investigated the effect of enteric polymers on uncoated hard capsule fabrication and dissolution properties. The polymers used in this study included HPMCPh and Eudragit L100-55. Eight different formulations based on HPMCPh, Eudragit, and gelatin were examined to identify the ideal formulation for the product of uncoated enteric hard capsules with preferred physicochemical and gastro-resistance properties. The results reveal that the capsules containing Eudragit (F1), HPMCPh (F2), Eudragit/HPMCPh/gelatin (F3), and Eudragit/gelatin (F4) are steady within the simulated stomach environment, and drug release does not occur for 120 minutes. The outcomes demonstrate that, among the proposed formulas, the F4 formula is suitable both in terms of capsulation form and delayed release properties and shows no microbial growth. The properties of the optimized sample were studied by FTIR, FESEM, tensile strength, humidity, and rheology. The results illustrated that gelatin-based hydrogels with Eudragit (F4) are potential candidates for manufacturing uncoated enteric hard capsules that inhibit drug release in a gastric pH medium and act as a pH-sensitive drug release system.

show abstract

Novel formulation of uncoated enteric capsule shells: Study the effect of gelling agents and salts on the rheology and physical properties

Cited by 3 publications

References 28 publications

Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug-released behavior of novel Eudragit L100-55/gelatin gastro-resistance uncoated capsule

Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug-released behavior of novel Eudragit L100-55/gelatin gastro-resistance uncoated capsule

Capsule-forming polymers

Evaluation of the effect of polymer composition on the rheological, mechanical properties and drug released behavior of novel Eudragit L100-55/ gelatin gastro-resistance uncoated capsule

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