Novel functionalized phenyl acetate derivatives of benzo [e]-bispyrone fused hybrids: Synthesis and biological activities

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Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may be appropriate to investigate the qualities and potential bioactivities of PDCs. This article provides an overview of the biomedical potentials, availability, and clinical use possibilities of PDCs, with a focus on their important modes of action, using information on various pharmacological qualities discovered. The data used in this study came from published research between 2015 and 2023. We reviewed a selection of databases, including PubMed, Scopus, Web of Science, and Google Scholar, during that period. In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.

Section: Results From the Reviewing And Their Related Discussionmentioning

confidence: 99%

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

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“…Kahtan et al, [72] developed and produced two groups of coumarin derivatives: pyrazolino [4,3-c] coumarin and its dioxole derivatives that were linearly annulated to the coumarin structure. Within the dioxolocoumarin derivatives, compounds (97a-c) were synthesized by initiating the Konevensgel reaction, where 1-(2,4,5-trihydroxyphenyl)ethenone ( 94) was condensed with ethyl 3-oxobutyrate (2) to form coumarin (95). This compound underwent a cyclization process facilitated by dichloromethane and anhydrous potassium fluoride, resulting in the formation of dioxolocoumarin (96).…”

Section: Dioxolo[g]coumarinsmentioning

confidence: 99%

“…Twenty-one pyranonocoumarins were effectively synthesized, and their biological activity was assessed by Mustafa et al. [95] Their synthesis route started with citretten (145), which produced 3-oxoglutaric acid (146) when concentrated H 2 SO 4 was used as a catalyst. Subsequently, compound (146) underwent the Pechmann reaction with derivatives of compound (24) to yield precursors of carboxylic acids (147a-c).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…The antibacterial activity of compounds (147a-u) was produced and assessed by Mustafa et al. [95] They also investigated these compounds' capacity to scavenge radicals. With IC 50 values of 92.67, 92.79, 95.43, 92.51, and 45.87 μM/ml, respectively, compounds (147c, 147d, 147j, 147p, and 147q) showed considerable antiradical capability against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.…”

Section: Miscellaneous Activitiesmentioning

confidence: 99%

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Annulated Heterocyclic[g]Coumarin Composites: Synthetic Approaches and Bioactive Profiling

Mazin Zeki,

Fakri Mustafa

2024

Coumarins, widely abundant natural heterocyclic compounds, are extensively employed in creating various biologically and pharmacologically potent substances. The hybridization of heterocycles presents a key opportunity to craft innovative multicyclic compounds with enhanced biological activity. Fusing different heterocyclic rings with the coumarin structure presents an intriguing method for crafting fresh hybrid compounds possessing remarkable biological effects. In the pursuit of creating heterocyclic‐fused coumarins, a wide range of annulated heterocyclic[g]coumarin composites has been introduced, displaying impressive biological potency. The influence of the linear attachment of heterocyclic rings to the coumarin structure on the biological performance of the resulting compounds has been investigated. This review centers on the synthetic methodologies, structural activity relationship investigation, and biological potentials of annulated heterocyclic[g]coumarin composites. We conducted searches across several databases, including Web of Science, Google Scholar, PubMed, and Scopus. After sieving, we ultimately identified and included 71 pertinent studies published between 2000 and the middle of 2023. This will provide valuable perspectives for medicinal chemists in the prospective design and synthesis of lead compounds with significant therapeutic effects, centered around heterocycle‐fused coumarin frameworks.

“…This degree was measured using a ROS identification kit (Abcam-AB113851) in compliance with the directions given by the supplier. [51] The standard deviation (SD) rankings from three distinct investigations were calculated in order to validate the results.…”

Section: Assay Of Oxidative Stress-mitigating Impactmentioning

confidence: 99%

Unveiling the Biomedical Applications of Novel Coumarins Isolated From Capsicum Annuum L. Seeds by a Multivariate Extraction Technique

Younes,

Mustafa

2024

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For the first time, kinetic thermomagnetic extraction is a novel approach presented in this work. It required the application of four distinct variables: rotation speed (50, 75, and 100 rpm), magnetic field (0.8, 1.2, and 1.6 T), time interval (30, 60, and 90 min), and temperature (45, 55, and 65°C). Numerous phytochemical categories were detected in the 81 crude chloroform extracts of green sweet bell pepper seeds that were collected, according to phytochemical analysis. Nine extracts were discovered to be linked to the coumarin chemical class and to have the same two extraction parameters: a 90‐minute extraction duration and a 55°C extraction temperature. To enable their coumarin contents to be chemically separated and chromatographically purified, two of these extracts containing coumarin were chosen. Four new phytocoumarins have been identified and their molecular structures distinguished using FTIR spectra, 1H‐NMR, 13C‐NMR, and mass analysis. The results demonstrated that the extracted phytocoumarins have exceptional oxidative stress‐mitigating characteristics, ranging from 71.51 to 81.48%, when compared to a positive control. Furthermore, they showed excellent cytotoxicity against the test malignant populations (IC50 values of 46.76–81.45 μg/ml). The isolates need to be taken into account as dual COX‐2/5‐LOX antagonists because they also showed a selective anti‐inflammatory effect