Novel gel formulations with catanionic aggregates enable prolonged drug release and reduced skin permeation

Dew, Noel; Edsman, Katarina; Björk, Erik

doi:10.1111/j.2042-7158.2011.01339.x

Cited by 9 publications

(9 citation statements)

References 54 publications

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“…CPDR=k 1 ·t m +k 2 ·t 2m (4) where, CPDR=Cumulative percent drug release, k 1 =Rate of drug diffusion due to Fickian diffusion, k 2 =Rate of drug diffusion due to polymer relaxation, and m=Composite diffusion exponent.…”

Section: -4 Mechanical Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Sagiri

Kasiviswanathan

Shaw

et al. 2016

Korean J. Chem. Eng.

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The current study describes the effect of the concentration of Span 60 (gelator) on the properties of oleogels. Mustard oil was chosen as the representative vegetable oil. Microscopy showed that an increase in the gelator concentration resulted in the increase in the gelator network density. Thermal studies (crystallization kinetics and differential scanning calorimetry) indicated a 2-stage crystallization process. An increase in the gelator proportion resulted in the increase in the compatibility amongst the oleogel components. The formation of gelator network was governed by the interaction amongst the hydroxyl groups of Span 60. A variation in the gelator proportion resulted in the alteration in the d-spacing, crystallite size and lattice strain. The variation in the above-mentioned properties was found to affect the viscoelastic properties of the oleogels as was predicted from the Weichert model. The drug release studies suggested that the drug diffusion due to the gelator network relaxation during drug release was predominant as compared to the Fickian diffusion. The results suggested that it is possible to alter not only the release profile of drugs but also the physical properties (of the oleogels) by tailoring the gelator concentration.

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Section: -4 Mechanical Propertiesmentioning

confidence: 99%

“…It promotes the formation of water-in-oil emulsions. Due to its non-ionic nature, Span 60 is biocompatible and non-irritant [4][5][6]. In addition to its afore-mentioned properties, Span 60 has been tried as a structuring agent for developing formulations for cosmetic, food and pharmaceutical applications [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Sagiri

Kasiviswanathan

Shaw

et al. 2016

Korean J. Chem. Eng.

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“…In most cases, two main strategies to improve release properties of catanionic vesicles are employed which are (1) incorporation of vesicles into the gels and (2) preparation of environment sensitive vesicles. Catanionic aggregates formed from drug and oppositely charged surfactant and then incorporated into the gel have been extensively studied by Edsman's group with the objective to utilize them for prolonged release [90][91][92][93][94][95][96]:…”

Section: Pharmaceutical Applications: Drug Delivery Systemsmentioning

confidence: 99%

“…(6) Release profiles of (1) alprenolol/SDS aggregates incorporated into the SoftCAT and Carbopol ® gels [95] and (2) tetracaine/SDS or capric acid aggregates incorporated into the SoftCAT and carbomer gels [96] have shown that prolonged drug release from this system enables prolonged skin penetration.…”

Section: Pharmaceutical Applications: Drug Delivery Systemsmentioning

confidence: 99%

Recent Advances in Catanionic Mixtures

Jurašin¹,

Šegota²,

Čadež³

et al. 2017

Application and Characterization of Surfactants

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Most surfactant mixtures display synergistic physicochemical properties, which have led to their extensive application in various technologies. Aqueous mixtures of two oppositely charged surfactants, so-called catanionic surfactant mixtures, exhibit the strongest synergistic effect, which is manifested as high surface activity, enhanced adsorption and a low critical aggregation concentration. In addition, catanionic systems display rich phase behavior and a range of nano and microstructures, including small spherical micelles, rod-like micelles as well as open and closed bilayers (vesicles). The spontaneous formation of catanionic vesicles is of special interest due to their various applications in nanotechnology and pharmaceutical formulations. In this chapter, the properties of catanionic mixtures of amphiphilic molecules with advantageous properties are discussed. Since numerous papers dealing with catanionic mixtures of monomeric surfactants already exist, the aim of this chapter is to summarize recent progress in mixtures of structurally different surfactants. At the end of the chapter, special emphasis is placed on applications of catanionic mixtures.

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“…The use of catanionic aggregates formed from drug compounds with oppositely-charged surfactants has received particular attention for drug delivery applications [24,25,26,27,28,29,30,31,32,33]. Aggregates made of ionic drugs and surfactants have proven to extend the drug release from synthetic gels from hours to days due to the presence of vesicles or entangled micelles [24,26].…”

Section: Introductionmentioning

confidence: 99%

Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses

et al. 2019

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This paper focuses on extending drug release duration from contact lenses by incorporating catanionic aggregates. The aggregates consist of a long-chain cationic surfactant, i.e., cetalkonium chloride (CKC), and an oppositely charged anti-inflammatory amphiphilic drug. We studied three non-steroidal anti-inflammatory (NSAID) drugs with different octanol–water partition coefficients; diclofenac sodium (DFNa), flurbiprofen sodium (FBNa), and naproxen sodium (NPNa). Confirmation of catanionic aggregate formation in solution was determined by steady and dynamic shear rheology measurements. We observed the increased viscosity, shear thinning, and viscoelastic behavior characteristic of wormlike micelles; the rheological data are reasonably well described using a Maxwellian fluid model with a single relaxation time. In vitro release experiments demonstrated that the extension in the drug release time is dependent on the ability of a drug to form viscoelastic catanionic aggregates. Such aggregates retard the diffusive transport of drug molecules from the contact lenses. Our study revealed that the release kinetics depends on the CKC concentration and the alkyl chain length of the cationic surfactant. We demonstrated that more hydrophobic drugs such as diclofenac sodium show a more extended release than less hydrophobic drugs such as naproxen sodium.

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Novel gel formulations with catanionic aggregates enable prolonged drug release and reduced skin permeation

Cited by 9 publications

References 54 publications

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Effect of sorbitan monostearate concentration on the thermal, mechanical and drug release properties of oleogels

Recent Advances in Catanionic Mixtures

Formation of Drug-Participating Catanionic Aggregates for Extended Delivery of Non-Steroidal Anti-Inflammatory Drugs from Contact Lenses

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