Novel gelatin microcapsule with bioavailability enhancement of ibuprofen using spray-drying technique

Li, Dong Xun; Oh, Yu-Kyuong; Lim, Soo-Jeong; Kim, Jong Oh; Yang, Haozhe; Sung, Jung Hoon; Yong, Chul Soon; Choi, Han‐Gon

doi:10.1016/j.ijpharm.2007.12.020

Cited by 90 publications

(76 citation statements)

References 16 publications

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“…IBU-PVA-SLS (2:3:2) has 6.3-fold smaller than untreated IBU. The SLS surfactant decrease the surface tension of IBU in ethanol-water solution allows IBU well dissolve and atomizer easily generate aerosol for spray drying process yielding smaller particles size [24]. The polymerization without SLS cause improved electrostatic interaction between particles, particles fly in all directions which caused difficulty in handling [33].…”

Section: Characteristic Of Particlesmentioning

confidence: 99%

“…Pyo et al, Kim et al, and Puri et al were using spray drying to control the amorphous states of the drugs because this state are often desired in order to achieve fast dissolution rates and high bioavailability [15,19,[20][21][22][23]. Xu et al, Li et al, and Shen et al improved solubility and dissolution of IBU by spray drying technique with using various polymer [1,21,24]. At previous research, microparticle was prepared by spray drying using nozzle or rotary atomizer which produced particle size 2-30 μm [9,[25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, an anionic surfactant such as sodium lauryl sulphate (SLS) was employed to prevent microcapsules from attaching to the inner wall of spray-drying chamber and to produce freeflowing powder. In the absence of SLS, strong electrostatic interaction among microparticle arisen from friction in spray drier making the powder fly in all directions [24]. Woo et al, Lee et al, and Mauludin et al, used SLS as a solubilizer or co-carrier for cyclosporin A and hesperidin by using spray drying [1,9,25].…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of solubility and dissolution of ibuprofen microparticle prepared by ultrasonic spray drying

Rachmaniar¹,

Panatarani²,

Joni³

et al. 2017

mpj

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Ibuprofen (IBU) is one of the most commonly used nonsteroidal anti-inflammatory drugs with high permeability and low solubility. The aims of this research is to improve the solubility and dissolution of the IBU by reducing particle size using ultrasonic spray drying method and utilizing watersoluble polymer (polyvinyl alcohol (PVA)) and surfactant (sodium lauryl sulphate (SLS)) for particles formulation. The results showed that increasing amount of PVA, smaller particle size of as-prepared IBU-PVA-SLS was obtained, 6.3-fold smaller than untreated IBU. The in vitro drug release study for simulated gastric fluid without enzymes (0.1 N HCl or Buffer pH 1.2) shows the dissolution of prepared IBU-PVA-SLS significantly increase 2.4-fold higher than untreated IBU for dissolution time of 30 minutes. While the solubility of the IBU-PVA-SLS was increased 4.7-fold compare to untreated IBU. In general, IBU possessing relatively high dissolution in intestinal fluid. In contrast, the finding of recent investigation on dissolution of IBU-PVA-SLS is significantly increase in gastric fluid, either due to smaller particles size or PVA-SLS. Thus, despite the PVA and SLS determine the particles formation during polymerization yielding smaller particle size, they also responsible for effective drug delivery system. It was concluded that PVA and SLS in ultrasonic spray drying technique for IBU preparation successfully reduces the particle size and effectively enhances the solubility and dissolution rate of poorly water-soluble IBU in 0.1 N HCl.

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Section: Characteristic Of Particlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancement of solubility and dissolution of ibuprofen microparticle prepared by ultrasonic spray drying

Rachmaniar¹,

Panatarani²,

Joni³

et al. 2017

mpj

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“…Prema literaturnim podacima, inkapsulati dobijeni sprej raspršivanjem imaju uniformnu raspodelu veličina čestica (10-100 µm), dok se liofilizacijom dobijaju čestice nepredvidivog oblika i veličine [6]. Kao što je predstavljeno u tabeli 1, liofilizovan i sprej osušen želatin ima endotermni pik na 80°C, odnosno na 89,5°C, što je u skladu sa literaturnim podacima, gde se endotermni pik želatina pojavljuje na 85°C [21]. Sprej osušeni ekstrakt ima pik na višoj temperaturi, u odnosu na liofilizovanu paralelu.…”

Section: Slika 6 -Sem Analiza žElatinskih Inkapsulata Ekstrakta Majčiunclassified

Gelatin as a carrier system for delivery of polyphenols compounds

Jovanović¹,

Djordjević²,

Lević³

et al. 2017

Tehnika

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“…Reduction of the particle size via micronisation or nanonisation leading to increased surface area (6); use of surfactants (7); lyophilisation (8); use of co-solvents (9); self-emulsification and self-microemulsification (10,11); inclusion of APIs into cyclodextrins (12); use of pro-drugs and drug derivatisation (13); formation of solid solutions or amorphous solids (14); microencapsulation (15) and inclusion of drug solutions or liquid drugs into soft gelatine capsules or sealed hard shell capsules (16) are some of the methods used to enhance dissolution characteristics of water-insoluble or poorly soluble drugs (Fig. 1).…”

mentioning

confidence: 99%