Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

Abstract

ABSTRACTof which 125 (82%) had BCP ALL and 28 (18%) had T-ALL. Genetically, 51/205 cases (25%) were positive for t(9;22)(q34;q11)/BCR-ABL, 19 (9%) for 11q23/MLL rearrangements and four (2%) for t(1;19)(q23;p13)/TCF3-PBX1. In addition, high hyperdiploidy was present in 13 cases (6.3%) and low hypodiploidy in two cases (1.0%) based on G-banding. The investigation was approved by the Research Ethics Committee of Lund University, and informed consent was provided according to the Declaration of Helsinki.

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

“…In 18%-33% of B-ALL cases. Safavi et al 72 Paulsson et al 73 Coyaud et al 100 Combined with TCF3-PBX1. In 41% of B-ALL cases.…”

“…In 18%-32% of B-ALL cases. Safavi et al 72 Paulsson et al 73 Marker for poor prognosis. Detected in 29%-35%…”

der(1)t(1;1)(p36;q11-q32) in hematopoietic malignancies

“…Associated with chromosome 5 and/or 7 anomalies in 4 AML (Fugazza et al, 1997;PicosCardenas et al, 2002;Preiss et al, 2006;Duhoux et al, 2011) and with t(9;22)(q34;q11) in 1 CML (Phan et al 2006) and 2 ALL cases (Uckun etal 1998;Schmidt-Hieber et al 2010). Very complex karyotypes (≥5 abnormalities) were observed in 15 patients (Bastard et al,1991;Fugazza et al, 1997;Rajkumar et al, 1999;Bang et al, 2006;Phan et al, 2006;Preiss et al, 2006;Nordgren et al, 2000;Schmidt-Hieber et al, 2010;Vekemans et al, 2010;Duhoux et al, 2011;Subramaniyam et al, 2011;Sawyer et al, 2014;Safavi et al 2015) while there seems to be an over-representation of complex anomalies in AML, ALL and B-cell hematological neoplasms.…”

“…Acute lymphoblastic leukemia 8 patients (Shikano et al,1994;Uckun et al 1998;Bruch et al 2003;Paulsson et al 2010;Schmidt-Hieber et al 2010;Duhoux et al 2011;Subramaniyam et al 2011;Safavi et al 2015) with predominantly B-cell phenotype. There were 5 children (Shikano et al,1994;Uckun et al 1998;Paulsson et al 2010;Duhoux et al, 2011) , one of them an infant patient (Bruch et al, 2003).…”

der(5)t(1;5)(q12-q25;q13-q35)

“…Acute lymphoblastic leukemia in 8 cases (Saikevych et al, 1991;Martin et al, 1996;Rieder et al, 1996;van den Berghe et al, 2000;Chang et al, 2006;Wehrli et al, 2009;Paulsson et al ., 2015;Safavi et al, 2015). Multiple myeloma in 11 cases (Smadja et al, 2001;Smadja et al, 2003.…”