2007
DOI: 10.1021/jm070044j
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Novel Generation of pH Indicators for Proton Magnetic Resonance Spectroscopic Imaging

Abstract: We describe the synthesis of 1,omega-di-1H-imidazoles 2 and 3, derived from l-threitol and d-mannitol, respectively, showing suitable magnetic and toxicological properties, as novel extracellular pH indicators for 1H spectroscopic imaging by magnetic resonance methods.

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Cited by 10 publications
(6 citation statements)
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“…[24] Imidazole-based compounds are attractive targets [25] because of their roles in several biological processes, [26] applications in coordination chemistry, [27] and also as an extracellular pH indicator for 1 H NMR spectroscopic imaging. [28] Imidazolyl alditols have also been used for the preparation of imidazolo sugars, studied as potential glycosidase inhibitors. [29] Scheme 4.…”
Section: Resultsmentioning
confidence: 99%
“…[24] Imidazole-based compounds are attractive targets [25] because of their roles in several biological processes, [26] applications in coordination chemistry, [27] and also as an extracellular pH indicator for 1 H NMR spectroscopic imaging. [28] Imidazolyl alditols have also been used for the preparation of imidazolo sugars, studied as potential glycosidase inhibitors. [29] Scheme 4.…”
Section: Resultsmentioning
confidence: 99%
“…In addition, the rapid elimination by renal clearance and the presence of only one H2 proton in IEPA and ISUCA limit the sensitivity of this approach for in vivo application. To overcome this issue, the design of diimidazole probes with higher polarity and double H2 resonance intensity is currently under investigation, with promising results for in vivo pHe measurements [37].…”
Section: Mrs-1 Hmentioning
confidence: 99%
“…It is now possible to study regional intratumoral variation of pH with MRS, which shows displacement of 31P (this displacement depends on the pH). To increase its sensitivity, IH proton spectroscopy with administration of contrast sensitive to changes in pH has been proposed with the objective of increasing the specificity and sensitivity of MRI in oncology [88].…”
Section: Metabolism: Mr Spectroscopymentioning
confidence: 99%