1994
DOI: 10.1159/000236599
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Novel Genes in the Human Major Histocompatibility Complex Class-ll Region

Abstract: Recent studies have identified a number of new genes mapping to the class-II region of the human major histocompatibility complex. Functionally these can be grouped into three broad categories: those encoding the new class-II-related genes DMA and DMB; those involved in aspects of class-I antigen-processing and presentation, and those with no apparent association with the immune system. There is evidence that further factors involved in class-II antigen presentation are located in the DMB to DQB1 interval.

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Cited by 6 publications
(1 citation statement)
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“…One of the hypotheses put forward to explain the maintenance of this spatial organization is the need for coordinate expression of multiple MHC genes operating at different levels of the complex antigen presentation pathway where all are required to mount an efficient immune response (23). Our results reveal a coordinate expression of the DMA and DMB genes with the structural MHC class II genes in both constitutive and inducible modes of expression.…”
Section: Discussionmentioning
confidence: 67%
“…One of the hypotheses put forward to explain the maintenance of this spatial organization is the need for coordinate expression of multiple MHC genes operating at different levels of the complex antigen presentation pathway where all are required to mount an efficient immune response (23). Our results reveal a coordinate expression of the DMA and DMB genes with the structural MHC class II genes in both constitutive and inducible modes of expression.…”
Section: Discussionmentioning
confidence: 67%