2021
DOI: 10.1155/2021/7619610
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Novel Genes Potentially Involved in Fibroblasts of Diabetic Wound

Abstract: Fibroblasts are the essential cell type of skin, highly involved in the wound regeneration process. In this study, we sought to screen out the novel genes which act important roles in diabetic fibroblasts through bioinformatic methods. A total of 811 and 490 differentially expressed genes (DEGs) between diabetic and normal fibroblasts were screened out in GSE49566 and GSE78891, respectively. Furthermore, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in type 2 diabetes were retrieved from… Show more

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Cited by 8 publications
(7 citation statements)
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“…37 Additionally, TGFBR1 may be involved in diabetic wound fibroblasts. 38 However, to date, there have been no reports of studies investigating the association between the two signature genes and DFU. Furthermore, there is a scarcity of clinical indicators available for diagnosing patients with DFU.…”
Section: Discussionmentioning
confidence: 99%
“…37 Additionally, TGFBR1 may be involved in diabetic wound fibroblasts. 38 However, to date, there have been no reports of studies investigating the association between the two signature genes and DFU. Furthermore, there is a scarcity of clinical indicators available for diagnosing patients with DFU.…”
Section: Discussionmentioning
confidence: 99%
“…HSPA2 has prominent roles in the morphological differentiation of male germ cells as well as their functional transformation during post-testicular sperm maturation ( 41 ). Zhu et al (2021) revealed the involvement of HSPA2 signaling pathway in fibroblast pathologies in diabetic wounds through integrated bioinformatic analyses ( 42 ). To enable to fulfil their multifarious influences on cell fate, Hsp70s has similarities in structure and redundancy in function; meanwhile, they also exhibit their own structural and biochemical characteristics, exhibiting pleiotropic and context-dependent roles in cells ( 30 , 43 , 44 ).…”
Section: Discussionmentioning
confidence: 99%
“…A comprehensive analysis of the Gene Expression Omnibus (GEO) database for diabetes-related changes has identified the Mitogen-activated protein kinase (MAPK) pathway as the predominant altered pathway in fibroblasts [160]. Gene differential expression studies have highlighted the roles of MAPKAPK3 (MAPKactivated protein kinase 3), HSPA2 (heat-shock protein family A member 2), TGFBR1 (transforming growth factor-beta receptor 1), and TP53 in regulating cellular apoptosis, proliferation, differentiation, and inflammation.…”
Section: The Role Of P53 In Different Layers Of Cells In Dwmentioning
confidence: 99%