Novel genome‐wide associations for effort valuation and psychopathology in children and adults
Nicholas H. Nguyen,
T. Mitchell Mazza,
Jonathan L. Hess
et al.
Abstract:The Research Domain Criteria (RDoC) initiative was established by the US National Institute of Mental Health as a multilevel, disorder‐agnostic framework for analysis of human psychopathology through designated domains and constructs, including the “Positive Valence Systems” domain focused on reward‐related behavior. This study investigates the reward valuation subconstruct of “effort” and its association with genetic markers, functional neurobiological pathways, and polygenic risk scores for psychopathology i… Show more
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