Novel Gold Nanoparticles: Green Synthesis with Eryngium thyrsoideum Boiss Extract, Characterization, and In Vivo Investigations on Inflammatory Gene Expression and Biochemical Parameters in Type 2 Diabetic Rats

Mahmoudi, Fariba; Mahmoudi, Farzaneh; Gollo, Khadijeh Haghighat; Amini, Mostafa M.

doi:10.1007/s12011-021-02819-7

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…The small changes in intensity and wave number of MCM-41 related peaks mentioned earlier were due to interactions between Au NP–decorated MCM-41 with CTAB. We noted that the four samples in Figure 5 b–e showed the characteristic band at the region (∼1090; 966 and 801 cm −1 ; 2918 and 2847), confirming the successful preparation of MCM-41 with CTAB and Au-decorated MCM-41 nanoparticles using the laser-ablation approach in the band (563, 1411, and 1635 cm −1 ) indicated peaks related to Au as well, as demonstrated by F. Mahmoudi et al [ 33 ].…”

Section: Resultssupporting

confidence: 76%

“…Figure 5 d,e show the FTIR spectra of the pulsed laser ablation of Au NP–decorated MCM-41 with different percentages of CTAB. The broad bands at 1635 cm −1 indicate to the carbonyl groups (C=O), whereas the bands observed in the range of 1411 and 1239 cm −1 indicated stretching vibrations of aliphatic C–H groups in extracts, as reported by F. Mahmoudi et al [ 33 ]. The small changes in intensity and wave number of MCM-41 related peaks mentioned earlier were due to interactions between Au NP–decorated MCM-41 with CTAB.…”

Section: Resultssupporting

confidence: 52%

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Fabrication and Characterization of Au-Decorated MCM-41 Mesoporous Spheres Using Laser-Ablation Technique

et al. 2022

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This study reports the synthesis of Au-decorated MCM-41 mesoporous nanoparticles using a laser-ablation technique. It was observed that the number of Au attached to MCM-41 nanostructures was dependent on the amount of encapsulated Cationic surfactant (cetyl ammonium bromide (CTAB) volume. The chemical group of the prepared nanoparticles was analyzed by FT-IR spectroscopy, where different absorption peaks corresponding to Au and MCM-41 were observed. The observed band region was ∼1090, 966, 801, 2918, and 1847 cm−1 for different samples, clearly confirming the successful preparation of MCM-41 with CTAB and Au-decorated MCM-41 nanoparticles using environmentally friendly laser-ablation approach. The surface morphology of the prepared nanoparticles were performed using TEM techniques. The TEM analysis of the MCM-41 specimen showed silica spheres with an average size of around 200 nm. Furthermore, Raman spectroscopy was done to evaluate the chemical structure of the prepared nanoparticles. It was seen that the prepared Au NPs decorated the MCM-41 system facilitated strong Raman peaks of CTAB. In addition, eight distinct Raman peaks were observed in the presence of Au NPs. This new functionalized method using the laser-ablation approach for mesoporous nanoparticles will participate effectively in multiple applications, especially the encapsulated molecule sensing and detection.

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Section: Resultssupporting

confidence: 76%

Section: Resultssupporting

confidence: 52%

Fabrication and Characterization of Au-Decorated MCM-41 Mesoporous Spheres Using Laser-Ablation Technique

et al. 2022

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“…In addition, they can significantly inhibit the expression of TNF-α and IL-6 genes in visceral adipose tissue of type 2 diabetes. The results show that Au NPs (9 nm, 2.5–5 mg/kg) are novel and efficient nanomaterials for diabetes management [ 68 ]. Gold nanoparticles (21 nm) also possess anti-inflammatory effects by downregulating tumor necrosis factor (TNF) α.…”

Section: Metabolic Syndrome and Othersmentioning

confidence: 99%

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Wang

Hsiao

et al. 2022

Molecules

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Gold has always been regarded as a symbol of nobility, and its shiny golden appearance has always attracted the attention of many people. Gold has good ductility, molecular recognition properties, and good biocompatibility. At present, gold is being used in many fields. When gold particles are as small as several nanometers, their physical and chemical properties vary with their size in nanometers. The surface area of a nano-sized gold surface has a special effect. Therefore, gold nanoparticles can, directly and indirectly, give rise to different biological activities. For example, if the surface of the gold is sulfided. Various substances have a strong chemical reactivity and are easy to combine with sulfhydryl groups; hence, nanogold is often used in biomedical testing, disease diagnosis, and gene detection. Nanogold is easy to bind to proteins, such as antibodies, enzymes, or cytokines. In fact, scientists use nanogold to bind special antibodies, as a tool for targeting cancer cells. Gold nanoparticles are also directly cytotoxic to cancer cells. For diseases caused by inflammation and oxidative damage, gold nanoparticles also have antioxidant and anti-inflammatory effects. Based on these unique properties, gold nanoparticles have become the most widely studied metal nanomaterials. Many recent studies have further demonstrated that gold nanoparticles are beneficial for humans, due to their functional pharmacological properties in a variety of diseases. The content of this review will be the application of gold nanoparticles in treating or diagnosing pressing diseases, such as cancers, retinopathy, neurological diseases, skin disorders, bowel diseases, bone cartilage disorders, cardiovascular diseases, infections, and metabolic syndrome. Gold nanoparticles have shown very obvious therapeutic and application potential.

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“…19 In addition, AuNPs inhibit the activation of MAPK, NF-kB, JAK/ STAT, and IKK-a/b signaling pathways, suppressing their downstream factors. 20 AuNPs reduce the expression of ICAM-1 in circulating polymorphonuclear (PMN) leukocytes and endothelial cells and inhibit leukocyte adhesion. 21 AuNPs scavenge ROS from mitochondria, inhibit the production of reactive oxygen and nitrogen species, and suppress oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

Aili,

Zhou,

Zhan

et al. 2023

J. Mater. Chem. B

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Novel Gold Nanoparticles: Green Synthesis with Eryngium thyrsoideum Boiss Extract, Characterization, and In Vivo Investigations on Inflammatory Gene Expression and Biochemical Parameters in Type 2 Diabetic Rats

Cited by 9 publications

References 21 publications

Fabrication and Characterization of Au-Decorated MCM-41 Mesoporous Spheres Using Laser-Ablation Technique

Fabrication and Characterization of Au-Decorated MCM-41 Mesoporous Spheres Using Laser-Ablation Technique

Pharmacological Role of Functionalized Gold Nanoparticles in Disease Applications

Anti-inflammatory role of gold nanoparticles in the prevention and treatment of Alzheimer's disease

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