Novel, green and sustainable route for synthesis of 5-aryl-4-phenyl-1,2,4-triazolidine-3-thiones

A Mechanistic Approach to Liquid‐Assisted Mechanochemical Synthesis of 5‐Aryl/Spiro‐[1,2,4]‐triazolidine‐3‐thiones

“…Our hypothesis was proven correct after analyzing the product and the spectral data were in fine agreement with those reported in literature. [30][31][32][33] The product obtained with all other active methylene compounds was same. It is also noteworthy that the best results were obtained with 1,3-dimethylbarbituric acid and therefore, the subsequent experiments were carried out by using it.…”

“…Mane and Pore reported sulfamic acid catalysed synthesis of 5‐aryl‐1,2,4‐triazolidine‐3‐thiones using aldehyde, hydrazine hydrate, and the not‐so‐easily available trimethylsilyl isothiocyanate [30] . Recently, Pore and his group also reported multicomponent synthesis of this class of compound with the aid of a Lewis acid‐surfactant (AlCl 3 ‐benzethonium chloride), by using phenyl isothiocyanate, hydrazine hydrate and aromatic aldehydes/cyclic ketones/isatins [31] . Mali and Telvekar used aldehydes and thiosemicarbazides, in the presence of DMAP, to synthesize 5‐aryl‐1,2,4‐triazolidine‐3‐thiones, in aqueous media [32] .…”

“…[30] Recently, Pore and his group also reported multicomponent synthesis of this class of compound with the aid of a Lewis acid-surfactant (AlCl 3 -benzethonium chloride), by using phenyl isothiocyanate, hydrazine hydrate and aromatic aldehydes/cyclic ketones/isatins. [31] Mali and Telvekar used aldehydes and thiosemicarbazides, in the presence of DMAP, to synthesize 5-aryl-1,2,4-triazolidine-3-thiones, in aqueous media. [32] This method also showed the reusability of the homogeneous DMAP-water system but lacked the prolonged reusability factor of DMAP and did not have chromatography free isolation of product.…”

Development of cellulose-based polymeric structures using dual functional ionic liquids

“…The FTIR-ATR spectrum of [BE]Cl showed a broad band near to 3428 cm −1 that can be attributed to O–H stretching vibration of water molecules present in its structure, which is broader in the case of [BE] based-ILs; a band in the range between 2987–2848 cm −1 that can be attributed to asymmetrical and symmetrical C–H stretching from methyl (–CH 3 ) and methylene (–CH 2 ) groups; a band near to 1513 cm −1 that can be assigned to aromatic ring stretching (C C–C); a band near to 1243, 1130 and 1064 cm −1 that can be attributed to alkyl aryl ether, alkyl ether and C–N stretching vibrations, respectively. 57 In the case of the [BE] based-ILs showed an additional band near to 1562 cm −1 that can be ascribed to carboxylate symmetric stretching (C O), indicating complete ionization of carboxylic acid and consequently, elucidation of the formation of the desired IL. In the case of [DDA]Br, the FTIR-ATR spectrum also showed a broad band near to 3420 cm −1 that can be attributed to O–H stretching vibration of water molecules present in its structure, which is also broader in the case of [DDA] based-ILs.…”

Thione Derivatives as Medicinally Important Compounds

“…This attraction is because of its application in organic synthesis and in their bonding characters. [16][17][18][19][20][21] Thiones are usually synthesized from ketones. In general, phosphorus pentasulfide [22] and Lawesson's reagent [23] are used as reagents to exchange S and O atoms.…”