Novel heptafluoroisopropyl N-phenylpyrazole aryl amides containing cyanoalkyl groups: Design, synthesis, insecticidal activity, docking studies and theoretical calculations

Design, Synthesis, and Acaricidal/Insecticidal Activities of New Phenylpyrazole Derivatives Comprising an Imide Moiety

“…Intermediates 2, 3, 4, and 5 were synthesized utilizing the previously reported method. 22 Compounds 9a−9b were obtained through a one-pot process combining Miyaura borate esterification and the Suzuki coupling reaction between intermediate 5 and materials 6a− 6b. Intermediates 12a−12c were synthesized through hydrolysis and acylation reactions.…”

“…Scheme illustrates the synthetic route for phenylpyrazole derivatives. Intermediates 2 , 3 , 4 , and 5 were synthesized utilizing the previously reported method . Compounds 9a – 9b were obtained through a one-pot process combining Miyaura borate esterification and the Suzuki coupling reaction between intermediate 5 and materials 6a – 6b .…”

“…Considering the insecticidal results, quantum chemical calculations of nicofluprole and the highly active compound A15 were analyzed utilizing Gaussian 09 software 25 as per our previously established methods. 22 The B3LYP/6-311G(d) basis set was adopted for all of the calculations.…”

“…Biological assays of the targeted compounds on T. cinnabarinus and several insect species were performed according to our previous methodology. 22 Target compounds (20 mg) were dissolved in 5 mL of acetone and subsequently diluted to the desired concentration by utilizing water containing 0.1% Tween 80. Each bioassay, comprising three replicates, was maintained at 25 ± 2 °C and 60 ± 5% relative humidity.…”