Novel heterocyclic ring-fused oleanolic acid derivatives as osteoclast inhibitors for osteoporosis

Abstract

A series of novel oleanolic acid (OA) derivatives were synthesized via modifications of the A-ring and C28-amides of OA, and their anti-bone resorption activities were evaluated in vitro and in vivo.

Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

“…The results showed that pyrazole derivative 70 ( Figure 54 ) (90.0% inhibition) showed better inhibitory activity than isoxazole derivative 71 ( Figure 54 ) (78.5% inhibition) and OA (11.4% inhibition). Therefore, pyrazole derivatives could be a promising anti-osteoporosis drug candidate [ 94 ].…”

Effective synthesis of novel furan-fused pentacyclic triterpenoids via anionic 5-exo dig cyclization of 2-alkynyl-3-oxotriterpene acids

“…Among them, considerable attention has been given to heterocyclic triterpenoids with various nitrogen, sulfur, and oxygen heterocycles. [9][10][11][12][13][14][15][16][17][18] The biological activity of triterpenoid heterocycles are promising and many of them have been studied as antitumor, [9][10][11][12][13] antiosteoporosis, 14,15 antiinflammatory 16 and antileishmanial agents. 17,18 Among this group of potentially biologically active compounds, furan triterpenoid derivatives have not been reported in the literature.…”