Novel high-strength bioabsorbable bone adhesives

Bou-Francis, Antony; Ghanem, Amyl

doi:10.3389/conf.fbioe.2016.01.02348

Cited by 1 publication

(2 citation statements)

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“…The poor interface strength in HAp/PCL composites is a remaining obstacle for their clinical use as implants [ 26 , 28 , 31 ]. The interface strength of composites is influenced by their component adhesion, which may have a mechanical, physical, chemical or combined origin.…”

Section: Resultsmentioning

confidence: 99%

“…Of particular interest are implants consisting of bioactive ceramics such as the osteoconductive hydroxyapatite and bioresorbable polymers such as polycaprolactone, which are both approved for medical applications by the Food and Drug Administration (FDA) [ 25 , 26 , 27 , 28 , 29 , 30 ]. A remaining obstacle for the use as implants is the poor interface strength between both materials [ 26 , 28 , 31 ], which might be improved by applying a surface texturing of the hydroxyapatite (HAp) ceramic.…”

Section: Introductionmentioning

confidence: 99%

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Hierarchical Surface Texturing of Hydroxyapatite Ceramics: Influence on the Adhesive Bonding Strength of Polymeric Polycaprolactone

Biggemann

Müller

Köllner

et al. 2020

JFB

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The tailored manipulation of ceramic surfaces gained recent interest to optimize the performance and lifetime of composite materials used as implants. In this work, a hierarchical surface texturing of hydroxyapatite (HAp) ceramics was developed to improve the poor adhesive bonding strength in hydroxyapatite and polycaprolactone (HAp/PCL) composites. Four different types of periodic surface morphologies (grooves, cylindric pits, linear waves and Gaussian hills) were realized by a ceramic micro-transfer molding technique in the submillimeter range. A subsequent surface roughening and functionalization on a micron to nanometer scale was obtained by two different etchings with hydrochloric and tartaric acid. An ensuing silane coupling with 3-aminopropyltriethoxysilane (APTES) enhanced the chemical adhesion between the HAp surface and PCL on the nanometer scale by the formation of dipole–dipole interactions and covalent bonds. The adhesive bonding strengths of the individual and combined surface texturings were investigated by performing single-lap compressive shear tests. All individual texturing types (macro, micro and nano) showed significantly improved HAp/PCL interface strengths compared to the non-textured HAp reference, based on an enhanced mechanical, physical and chemical adhesion. The independent effect mechanisms allow the deliberately hierarchical combination of all texturing types without negative influences. The hierarchical surface-textured HAp showed a 6.5 times higher adhesive bonding strength (7.7 ± 1.5 MPa) than the non-textured reference, proving that surface texturing is an attractive method to optimize the component adhesion in composites for potential medical implants.

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Section: Resultsmentioning

confidence: 99%