Novel highly selective and sensitive fluorescent sensor for copper detection based on N-acylhydrazone acridone derivative

Investigation of Stepwise and Stoichiometric Palladium-Mediated ortho-C–H Bond Arylation and Alkylation of 9(10H)-Acridinone

“…It is composed of two benzene units linked by both a carbonyl and a secondary amino groups and adopts a planar conformation. In terms of physical properties, acridinone derivatives exhibit strong emission and good photostability, enabling their applications as fluorescent antennae in chemosensors . In conventional synthesis, 9­(10 H )-acridinones can be approached through two synthetic routes as shown in Scheme .…”

Synthesis and biological evaluation of novel isoxazole derivatives from acridone

“…First, acridone was prepared by Ullmann condensation of o ‐bromobenzoic acid with p ‐toluidine or aniline in the presence of potassium carbonate and copper in isoamyl alcohol at reflux to produce 2‐arylamino benzoic acids, [ 19,20 ] which was then cyclized with polyphosphoric acid at 120°C during 4 h to produce compounds 2a , b . The propargylation of the acridone ring was attempted by refluxing excess of propargyl bromide with acridone derivatives in the presence of anhydrous potassium carbonate as base and tetra‐ n ‐butylammonium bromide (TBAB) as catalyst (PTC) in dimethylformamide (DMF) at 70°C.…”

“Turn‐on” Fluorescence Chemosensor Based Probing of Cu2+ with Excellent Sensitivity: Experimental Study, DFT Calculations and Application in Living Cells and Natural Waters

“…[5,9,10,15] By contrast, fluorescence sensing-based techniques for Cu 2 + detection require relatively simple instruments and attract more attention on account of significant advantages, including real time and in situ analysis, fast response, convenient operation, and high sensitivity. [4,12,16,[18][19][20][21][22][23][24] Hence, the above merits make fluorescent based strategy as an indispensable tool in disease diagnosis and treatment, biomedical area and also other fields. [10] Previously, a lot of fluorescence probes consisting of molecules such as rhodamine, [25] [5]helicene, [2] coumarin, [15,16] benzimidazole, [18] calixarene, [18] naphtalimide, [1,11] Schiff base, [26][27][28] aldazine, [29] thiocarbonohydrazone, [30] and quinoline [12] have been published in the literature for the recognition of copper ions.…”

“…Although these methods provide accurate measurements in matrixes, many of them usually suffer from some restrictions like insufficient sensitivity, requirement of highly trained operators, and expensive and sophisticated instrumentations [5,9,10,15] . By contrast, fluorescence sensing‐based techniques for Cu 2+ detection require relatively simple instruments and attract more attention on account of significant advantages, including real time and in situ analysis, fast response, convenient operation, and high sensitivity [4,12,16,18–24] . Hence, the above merits make fluorescent based strategy as an indispensable tool in disease diagnosis and treatment, biomedical area and also other fields [10] …”