Novel HLA‐B alleles associated with antigens in the 7C CREG

Steiner, Noriko; Jones, P.; Kosman, C.; Edson, Suni M.; Rizzuto, Gabrielle; Gans, C.P.; Mitton, W.; Koester, R.; Marino, Susana R.; Ng, Jennifer; Hartzman, Robert J.; Hurley, Carolyn Katovich

doi:10.1034/j.1399-0039.2001.057005486.x

Cited by 8 publications

(5 citation statements)

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“…Comparable changes have been observed in B*2716, B*2718 and B*2723. However, the serological recognition of these alleles has not yet been described (46) .…”

Section: Discussionmentioning

confidence: 99%

B*27 in molecular diagnostics: Impact of new alleles and polymorphism outside exons 2 and 3

2002

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HLA-B*27 is known to be associated with ankylosing spondylitis and several methods have been applied to determine its presence or absence. In this report two molecular methods were used for detection of B*27. The polymerase chain reaction sequence-specific primer (PCR-SSP) method was performed to detect the presence or absence of B*27, whereas the sequence-based typing method (SBT) was used to identify the B*27 subtype. The PCR-SSP method used to detect B*27 was updated to enable the detection of all B*27 alleles. The typing results obtained by this method were compared with the serological typings of 262 individuals. Fifty of them were found to be B*27 positive by PCR-SSP and 46 also showed positive serological reactions with B27-specific sera. The four discrepancies were the result of the presence of B*2712 in three individuals and B*2715 in one individual; both alleles showed no serological reactions with B27-specific antisera. With SBT the sequences of exons 1 through 4 were determined to unequivocally assign the B*27 alleles. Eleven different subtypes were detected in 78 individuals, including three new B*27 alleles: B*27054, B*2715 and B*2717. The allele B*27054 showed an allelic drop out when exon 3 was amplified. Three differences with B*27052 were demonstrated; one in exon 1, one in intron 1 and one in intron 2, the latter being responsible for the allelic drop out. The B*2715 allele was serologically not detectable with several B27-specific sera, but showed Bw4-positive reactions. The sequence of B*2715 showed two mismatches with B*2704. The sequence of B*2717 showed one mismatch with B*27052 at position 248 (A-->T), which was considered to be a conserved position in all B alleles.

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“…Comparable changes have been observed in B*2716, B*2718 and B*2723. However, the serological recognition of these alleles has not yet been described (46) .…”

Section: Discussionmentioning

confidence: 99%

B*27 in molecular diagnostics: Impact of new alleles and polymorphism outside exons 2 and 3

2002

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“…Among HLA-B alleles, B*53 and B*07 have previously been reported to be involved in recombination events; B*53:31 was identified as arisen by a gene conversion event between B*35:03:01 and B*44:02 or B*13:02 (Adamek et al 2015 ), B*07 has been reported as donor allele group for the alleles B*44:150 and B*08:79 (Balas et al 2012a , b ), but also for the allele A*23:31 that originated from an interlocus gene conversion (Lazaro et al 2012 ). Several B*07 alleles might also have been the result of a recombination event themselves, like B*07:12 , that seems to be a recombination between B*07:02 and either B*35 , 53 , or 58 , sharing intron 2 and first part of exon 3 sequences with the latter allele groups (Steiner et al 2001 ). Also within the C*03 allele group, intralocus recombination was detected, for example, the C*03:58 allele that turned out to be a hybrid of C*03:03:01 and C*01:03 (Lazaro et al 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles

Voorter,

Groeneweg,

Olieslagers

et al. 2024

Immunogenetics

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In the past, identification of HLA alleles was limited to sequencing the region of the gene coding for the peptide binding groove, resulting in a lack of sequence information in the HLA database, challenging HLA allele assignment software programs. We investigated full-length sequences of 19 HLA class I and 7 HLA class II alleles, and we extended another 47 HLA class I alleles with sequences of 5′ and 3′ UTR regions that were all not yet available in the IPD-IMGT/HLA database. We resolved 8638 unknown nucleotides in the coding sequence of HLA class I and 2139 of HLA class II. Furthermore, with full-length sequencing of the 26 alleles, more than 90 kb of sequence information was added to the non-coding sequences, whereas extension of the 47 alleles resulted in the addition of 5.5 kb unknown nucleotides to the 5′ UTR and > 31.7 kb to the 3′ UTR region. With this information, some interesting features were observed, like possible recombination events and lineage evolutionary origins. The continuing increase in the availability of full-length sequences in the HLA database will enable the identification of the evolutionary origin and will help the community to improve the alignment and assignment accuracy of HLA alleles.

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“…HLA‐B*07:162 is identical to HLA‐B*07:12 in exon 2 but has one nucleotide substitution at position 419 (A to C) in exon 3 (Figure A). HLA‐B*07:12 was first reported in two African Americans but was not seen among Taiwanese. On inspection of the HLA‐B sequences commonly found in Taiwanese , we found that the sequence motif at positions 353–419 of B*07:162 was also present in B*35:01:01 and B*58:01:01 (Figure A).…”

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confidence: 99%

Identification of a novel HLA‐B allele, B07:162*, in a Taiwanese individual

et al. 2013

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Novel HLA‐B alleles associated with antigens in the 7C CREG

Abstract: This paper describes 9 novel HLA-B locus alleles. All of the alleles carry sequence motifs observed in other HLA-B alleles.

Cited by 8 publications

References 10 publications

B*27 in molecular diagnostics: Impact of new alleles and polymorphism outside exons 2 and 3

B*27 in molecular diagnostics: Impact of new alleles and polymorphism outside exons 2 and 3

Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles

Identification of a novel HLA‐B allele, B07:162*, in a Taiwanese individual

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Novel HLA‐B alleles associated with antigens in the 7C CREG

Abstract: This paper describes 9 novel HLA-B locus alleles. All of the alleles carry sequence motifs observed in other HLA-B alleles.

Cited by 8 publications

References 10 publications

B*27 in molecular diagnostics: Impact of new alleles and polymorphism outside exons 2 and 3

B*27 in molecular diagnostics: Impact of new alleles and polymorphism outside exons 2 and 3

Resolving unknown nucleotides in the IPD-IMGT/HLA database by extended and full-length sequencing of HLA class I and II alleles

Identification of a novel HLA‐B allele, B*07:162, in a Taiwanese individual

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Identification of a novel HLA‐B allele, B07:162*, in a Taiwanese individual