Novel Hybrid Nanostructure Hydrogel for Treating Fungal Infections: Design and Evaluation

Khan, Muhammad Uzair; Rehman, Asim ur; Khan, Muhammad Farhan Ali; Ahmed, Naveed; Rashid, Sheikh Abdur; Munawar, Khurram Shahzad

doi:10.1007/s12668-024-01419-8

Cited by 3 publications

(1 citation statement)

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“…Nanoparticles were the formulation that most permeated through rat skin, followed by the nanostructured hydrogel and finally the dispersion. The authors conclude that the nanostructured hydrogel was a potential candidate for topical delivery since the formulation exhibited significant activity in the in vitro antifungal study [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

Nanocomposite Gels Loaded with Flurbiprofen: Characterization and Skin Permeability Assessment in Different Skin Species

El Bejjaji,

Ramos-Yacasi,

Suñer-Carbó

et al. 2024

Gels

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Nanocomposite gels consist of nanoparticles dispersed in a gel matrix. The main aim of this work was to develop nanocomposite gels for topical delivery of Flurbiprofen (FB) for humans and farm animals. Nanocomposite gels were prepared stemming from nanoparticles (NPs) freeze-dried with two different cryoprotectants, D-(+)-trehalose (NPs-TRE) and polyethylene glycol 3350 (NPs-PEG), sterilized by gamma (γ) irradiation, and gelled with Sepigel® 305. Nanocomposite gels with FB-NPs-TRE and FB-NPs-PEG were physiochemically characterized in terms of appearance, pH, morphological studies, porosity, swelling, degradation, extensibility, and rheological behavior. The drug release profile and kinetics were assessed, as well as, the ex vivo permeation of FB was assessed in human, porcine and bovine skin. In vivo studies in healthy human volunteers were tested without FB to assess the tolerance of the gels with nanoparticles. Physicochemical studies demonstrated the suitability of the gel formulations. The ex vivo skin permeation capacity of FB-NPs nanocomposite gels with different cryoprotectants allowed us to conclude that these formulations are suitable topical delivery systems for human and veterinary medicine. However, there were statistically significant differences in the permeation of each formulation depending on the skin. Results suggested that FB-NPs-PEG nanocomposite gel was most suitable for human and porcine skin, and the FB-NPs-TRE nanocomposite gel was most suitable for bovine skin.

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Section: Resultsmentioning

confidence: 99%